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http://purl.uniprot.org/citations/29316899http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Backgrounds

Long non-coding RNA (LncRNA) have been reported to be involved in the pathogenesis of neurodegenerative diseases, but whether it can serve as a biomarker for Alzheimer disease (AD) is not yet known.

Methods

The present study selected four specific LncRNA (17A, 51A, BACE1 and BC200) as possible AD biomarker. RT-qPCR was performed to validate the LncRNA. Receiver operating characteristic curve (ROC) and area under the ROC curve (AUC) were applied to study the potential of LncRNA as a biomarker in a population of 88 AD patients and 72 control individuals.

Results

We found that the plasma LncRNA BACE1 level of AD patients was significantly higher than that of healthy controls (p = 0.006). Plasma level of LncRNA 17A, 51A and BC200 did not show a significant difference between two groups (p = 0.098, p = 0.204 and p = 0.232, respectively). ROC curve analysis showed that LncRNA BACE1 was the best candidate of these LncRNA (95% CI: 0.553-0.781, p = 0.003). In addition, no correlation was found for expression of these LncRNA in both control and AD groups with age or MMSE scale (p > 0.05).

Conclusions

Our present study compared the plasma level of four LncRNA between AD and non-AD patients, and found that the level of the BACE1 is increased in the plasma of AD patients and have a high specificity (88%) for AD, indicating BACE1 may be a potential candidate biomarker to predict AD."xsd:string
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http://purl.uniprot.org/citations/29316899http://purl.uniprot.org/core/author"Feng L."xsd:string
http://purl.uniprot.org/citations/29316899http://purl.uniprot.org/core/author"Wang Z."xsd:string
http://purl.uniprot.org/citations/29316899http://purl.uniprot.org/core/author"Chen S.Y."xsd:string
http://purl.uniprot.org/citations/29316899http://purl.uniprot.org/core/author"Liao Y.T."xsd:string
http://purl.uniprot.org/citations/29316899http://purl.uniprot.org/core/author"He J.C."xsd:string
http://purl.uniprot.org/citations/29316899http://purl.uniprot.org/core/author"Fan H.H."xsd:string
http://purl.uniprot.org/citations/29316899http://purl.uniprot.org/core/author"Xie C.L."xsd:string
http://purl.uniprot.org/citations/29316899http://purl.uniprot.org/core/author"Su Z.P."xsd:string
http://purl.uniprot.org/citations/29316899http://purl.uniprot.org/core/date"2018"xsd:gYear
http://purl.uniprot.org/citations/29316899http://purl.uniprot.org/core/name"BMC Neurol"xsd:string
http://purl.uniprot.org/citations/29316899http://purl.uniprot.org/core/pages"4"xsd:string
http://purl.uniprot.org/citations/29316899http://purl.uniprot.org/core/title"Plasma long non-coding RNA BACE1 as a novel biomarker for diagnosis of Alzheimer disease."xsd:string
http://purl.uniprot.org/citations/29316899http://purl.uniprot.org/core/volume"18"xsd:string
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