| http://purl.uniprot.org/citations/29317426 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29317426 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29317426 | http://www.w3.org/2000/01/rdf-schema#comment | "A hallmark of macroautophagy is the covalent lipidation of LC3 and insertion into the double-membrane phagophore, which is driven by the ATG16L1/ATG5-ATG12 complex. In contrast, non-canonical autophagy is a pathway through which LC3 is lipidated and inserted into single membranes, particularly endolysosomal vacuoles during cell engulfment events such as LC3-associated phagocytosis. Factors controlling the targeting of ATG16L1 to phagophores are dispensable for non-canonical autophagy, for which the mechanism of ATG16L1 recruitment is unknown. Here we show that the WD repeat-containing C-terminal domain (WD40 CTD) of ATG16L1 is essential for LC3 recruitment to endolysosomal membranes during non-canonical autophagy, but dispensable for canonical autophagy. Using this strategy to inhibit non-canonical autophagy specifically, we show a reduction of MHC class II antigen presentation in dendritic cells from mice lacking the WD40 CTD Further, we demonstrate activation of non-canonical autophagy dependent on the WD40 CTD during influenza A virus infection. This suggests dependence on WD40 CTD distinguishes between macroautophagy and non-canonical use of autophagy machinery."xsd:string |
| http://purl.uniprot.org/citations/29317426 | http://purl.org/dc/terms/identifier | "doi:10.15252/embj.201797840"xsd:string |
| http://purl.uniprot.org/citations/29317426 | http://purl.org/dc/terms/identifier | "doi:10.15252/embj.201797840"xsd:string |
| http://purl.uniprot.org/citations/29317426 | http://purl.uniprot.org/core/author | "Wileman T."xsd:string |
| http://purl.uniprot.org/citations/29317426 | http://purl.uniprot.org/core/author | "Wileman T."xsd:string |
| http://purl.uniprot.org/citations/29317426 | http://purl.uniprot.org/core/author | "Fletcher K."xsd:string |
| http://purl.uniprot.org/citations/29317426 | http://purl.uniprot.org/core/author | "Fletcher K."xsd:string |
| http://purl.uniprot.org/citations/29317426 | http://purl.uniprot.org/core/author | "Arasteh J.M."xsd:string |
| http://purl.uniprot.org/citations/29317426 | http://purl.uniprot.org/core/author | "Arasteh J.M."xsd:string |
| http://purl.uniprot.org/citations/29317426 | http://purl.uniprot.org/core/author | "Beale R."xsd:string |
| http://purl.uniprot.org/citations/29317426 | http://purl.uniprot.org/core/author | "Beale R."xsd:string |
| http://purl.uniprot.org/citations/29317426 | http://purl.uniprot.org/core/author | "Carding S.R."xsd:string |
| http://purl.uniprot.org/citations/29317426 | http://purl.uniprot.org/core/author | "Carding S.R."xsd:string |
| http://purl.uniprot.org/citations/29317426 | http://purl.uniprot.org/core/author | "Florey O."xsd:string |
| http://purl.uniprot.org/citations/29317426 | http://purl.uniprot.org/core/author | "Florey O."xsd:string |
| http://purl.uniprot.org/citations/29317426 | http://purl.uniprot.org/core/author | "Gammoh N."xsd:string |
| http://purl.uniprot.org/citations/29317426 | http://purl.uniprot.org/core/author | "Gammoh N."xsd:string |
| http://purl.uniprot.org/citations/29317426 | http://purl.uniprot.org/core/author | "Jacquin E."xsd:string |
| http://purl.uniprot.org/citations/29317426 | http://purl.uniprot.org/core/author | "Jacquin E."xsd:string |
| http://purl.uniprot.org/citations/29317426 | http://purl.uniprot.org/core/author | "Mayer U."xsd:string |
| http://purl.uniprot.org/citations/29317426 | http://purl.uniprot.org/core/author | "Mayer U."xsd:string |
| http://purl.uniprot.org/citations/29317426 | http://purl.uniprot.org/core/author | "Ulferts R."xsd:string |
| http://purl.uniprot.org/citations/29317426 | http://purl.uniprot.org/core/author | "Ulferts R."xsd:string |