| http://purl.uniprot.org/citations/29317623 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29317623 | http://www.w3.org/2000/01/rdf-schema#comment | "Overeating and arrhythmic feeding promote obesity and diabetes. Glucagon-like peptide-1 receptor (GLP-1R) agonists are effective anti-obesity drugs but their use is limited by side effects. Here we show that oral administration of the non-calorie sweetener, rare sugar D-allulose (D-psicose), induces GLP-1 release, activates vagal afferent signaling, reduces food intake and promotes glucose tolerance in healthy and obese-diabetic animal models. Subchronic D-allulose administered at the light period (LP) onset ameliorates LP-specific hyperphagia, visceral obesity, and glucose intolerance. These effects are blunted by vagotomy or pharmacological GLP-1R blockade, and by genetic inactivation of GLP-1R signaling in whole body or selectively in vagal afferents. Our results identify D-allulose as prominent GLP-1 releaser that acts via vagal afferents to restrict feeding and hyperglycemia. Furthermore, when administered in a time-specific manner, chronic D-allulose corrects arrhythmic overeating, obesity and diabetes, suggesting that chronotherapeutic modulation of vagal afferent GLP-1R signaling may aid in treating metabolic disorders."xsd:string |
| http://purl.uniprot.org/citations/29317623 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-017-02488-y"xsd:string |
| http://purl.uniprot.org/citations/29317623 | http://purl.uniprot.org/core/author | "Hara H."xsd:string |
| http://purl.uniprot.org/citations/29317623 | http://purl.uniprot.org/core/author | "Okada T."xsd:string |
| http://purl.uniprot.org/citations/29317623 | http://purl.uniprot.org/core/author | "Nakata M."xsd:string |
| http://purl.uniprot.org/citations/29317623 | http://purl.uniprot.org/core/author | "Sato T."xsd:string |
| http://purl.uniprot.org/citations/29317623 | http://purl.uniprot.org/core/author | "Yamada Y."xsd:string |
| http://purl.uniprot.org/citations/29317623 | http://purl.uniprot.org/core/author | "Yada T."xsd:string |
| http://purl.uniprot.org/citations/29317623 | http://purl.uniprot.org/core/author | "Arai T."xsd:string |
| http://purl.uniprot.org/citations/29317623 | http://purl.uniprot.org/core/author | "Aoki R."xsd:string |
| http://purl.uniprot.org/citations/29317623 | http://purl.uniprot.org/core/author | "Hayakawa M."xsd:string |
| http://purl.uniprot.org/citations/29317623 | http://purl.uniprot.org/core/author | "Iwasaki Y."xsd:string |
| http://purl.uniprot.org/citations/29317623 | http://purl.uniprot.org/core/author | "Masuda C."xsd:string |
| http://purl.uniprot.org/citations/29317623 | http://purl.uniprot.org/core/author | "Kumari P."xsd:string |
| http://purl.uniprot.org/citations/29317623 | http://purl.uniprot.org/core/author | "Tokuda M."xsd:string |
| http://purl.uniprot.org/citations/29317623 | http://purl.uniprot.org/core/author | "Drucker D.J."xsd:string |
| http://purl.uniprot.org/citations/29317623 | http://purl.uniprot.org/core/author | "Goswami C."xsd:string |
| http://purl.uniprot.org/citations/29317623 | http://purl.uniprot.org/core/author | "Dezaki K."xsd:string |
| http://purl.uniprot.org/citations/29317623 | http://purl.uniprot.org/core/author | "Hira T."xsd:string |
| http://purl.uniprot.org/citations/29317623 | http://purl.uniprot.org/core/author | "Sendo M."xsd:string |
| http://purl.uniprot.org/citations/29317623 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29317623 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/29317623 | http://purl.uniprot.org/core/pages | "113"xsd:string |
| http://purl.uniprot.org/citations/29317623 | http://purl.uniprot.org/core/title | "GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose."xsd:string |