| http://purl.uniprot.org/citations/29320728 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29320728 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29320728 | http://www.w3.org/2000/01/rdf-schema#comment | "The TCP-1 ring complex (TRiC) is a multi-subunit group II chaperonin that assists nascent or misfolded proteins to attain their native conformation in an ATP-dependent manner. Functional studies in yeast have suggested that TRiC is an essential and generalized component of the protein-folding machinery of eukaryotic cells. However, TRiC's involvement in specific cellular processes within multicellular organisms is largely unknown because little validation of TRiC function exists in animals. Our in vivo analysis reveals a surprisingly specific role of TRiC in the biogenesis of skeletal muscle α-actin during sarcomere assembly in myofibers. TRiC acts at the sarcomere's Z-disk, where it is required for efficient assembly of actin thin filaments. Binding of ATP specifically by the TRiC subunit Cct5 is required for efficient actin folding in vivo. Furthermore, mutant α-actin isoforms that result in nemaline myopathy in patients obtain their pathogenic conformation via this function of TRiC."xsd:string |
| http://purl.uniprot.org/citations/29320728 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2017.12.069"xsd:string |
| http://purl.uniprot.org/citations/29320728 | http://purl.uniprot.org/core/author | "Li M."xsd:string |
| http://purl.uniprot.org/citations/29320728 | http://purl.uniprot.org/core/author | "Li M."xsd:string |
| http://purl.uniprot.org/citations/29320728 | http://purl.uniprot.org/core/author | "Berger J."xsd:string |
| http://purl.uniprot.org/citations/29320728 | http://purl.uniprot.org/core/author | "Berger J."xsd:string |
| http://purl.uniprot.org/citations/29320728 | http://purl.uniprot.org/core/author | "Berger S."xsd:string |
| http://purl.uniprot.org/citations/29320728 | http://purl.uniprot.org/core/author | "Berger S."xsd:string |
| http://purl.uniprot.org/citations/29320728 | http://purl.uniprot.org/core/author | "Jacoby A.S."xsd:string |
| http://purl.uniprot.org/citations/29320728 | http://purl.uniprot.org/core/author | "Jacoby A.S."xsd:string |
| http://purl.uniprot.org/citations/29320728 | http://purl.uniprot.org/core/author | "Stewart A.G."xsd:string |
| http://purl.uniprot.org/citations/29320728 | http://purl.uniprot.org/core/author | "Stewart A.G."xsd:string |
| http://purl.uniprot.org/citations/29320728 | http://purl.uniprot.org/core/author | "Currie P.D."xsd:string |
| http://purl.uniprot.org/citations/29320728 | http://purl.uniprot.org/core/author | "Currie P.D."xsd:string |
| http://purl.uniprot.org/citations/29320728 | http://purl.uniprot.org/core/author | "Bavi N."xsd:string |
| http://purl.uniprot.org/citations/29320728 | http://purl.uniprot.org/core/author | "Bavi N."xsd:string |
| http://purl.uniprot.org/citations/29320728 | http://purl.uniprot.org/core/author | "Arner A."xsd:string |
| http://purl.uniprot.org/citations/29320728 | http://purl.uniprot.org/core/author | "Arner A."xsd:string |
| http://purl.uniprot.org/citations/29320728 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29320728 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29320728 | http://purl.uniprot.org/core/name | "Cell Rep."xsd:string |
| http://purl.uniprot.org/citations/29320728 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/29320728 | http://purl.uniprot.org/core/pages | "313-322"xsd:string |