| http://purl.uniprot.org/citations/29323718 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29323718 | http://www.w3.org/2000/01/rdf-schema#comment | "The study aimed to investigate the impact of miR-182 and FOXO1 on S. japonica-induced hepatic fibrosis. Microarray analysis was performed to screen out differential expressed miRNAs and mRNAs. Rat hepatic fibrosis model and human hepatocellular cell line LX-2 were used to study the effect of miR-182 and FOXO1. qRT-PCR and Western blot were used to detect the expression of miR-182, FOXO1 or other fibrosis markers. The targeting relationship between FOXO1 and miR-182 was verified by luciferase reporter assay. Immunohistochemistry or immunofluorescence staining was conducted to detect FOXO1 or α-SMA in rat hepatic tissues. Cell viability and apoptosis were detected by MTT assay and flow cytometry. The expression of PI3K/AKT pathway-related proteins was detected by Western blot. miR-182 was highly expressed in liver fibrosis samples, and FOXO1 expression was negatively correlated with miR-182 expression. After transfection of miR-182, FOXO1 expression was down-regulated, with the results of LX-2 cells proliferation inhibition and apoptosis induction, as well as the aggravation of rat hepatic fibrosis. The expression of p-AKT/AKT and p-S6/S6 was increased, meaning that the PI3K/AKT signal pathway was activated. The results were reversed when treated with Wortmannin (PI3K inhibitor). After transfection of miR-182 inhibitor, FOXO1 expression was up-regulated, LX-2 cell proliferation was inhibited, and apoptosis rate was increased. High-expressed miR-182 and low-expressed FOXO1 promoted proliferation and inhibiting apoptosis on liver fibrosis cells, stimulating the development of S. japonica-induced hepatic fibrosis through feeding back to PI3K/AKT signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/29323718 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcp.26469"xsd:string |
| http://purl.uniprot.org/citations/29323718 | http://purl.uniprot.org/core/author | "Fan X."xsd:string |
| http://purl.uniprot.org/citations/29323718 | http://purl.uniprot.org/core/author | "Kong H."xsd:string |
| http://purl.uniprot.org/citations/29323718 | http://purl.uniprot.org/core/author | "Huang Y."xsd:string |
| http://purl.uniprot.org/citations/29323718 | http://purl.uniprot.org/core/author | "Huang J."xsd:string |
| http://purl.uniprot.org/citations/29323718 | http://purl.uniprot.org/core/author | "Song Q."xsd:string |
| http://purl.uniprot.org/citations/29323718 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/29323718 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/29323718 | http://purl.uniprot.org/core/author | "Tao R."xsd:string |
| http://purl.uniprot.org/citations/29323718 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29323718 | http://purl.uniprot.org/core/name | "J Cell Physiol"xsd:string |
| http://purl.uniprot.org/citations/29323718 | http://purl.uniprot.org/core/pages | "6693-6704"xsd:string |
| http://purl.uniprot.org/citations/29323718 | http://purl.uniprot.org/core/title | "Effect of miR-182 on hepatic fibrosis induced by Schistosomiasis japonica by targeting FOXO1 through PI3K/AKT signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/29323718 | http://purl.uniprot.org/core/volume | "233"xsd:string |
| http://purl.uniprot.org/citations/29323718 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29323718 |
| http://purl.uniprot.org/citations/29323718 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29323718 |
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| http://purl.uniprot.org/uniprot/#_A1E251-mappedCitation-29323718 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29323718 |