| http://purl.uniprot.org/citations/29326316 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29326316 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveFibronectin containing extra domain A (Fn-EDA) is an endogenous ligand of TLR4 (toll-like receptor 4) and is abundant in the extracellular matrix of advanced atherosclerotic lesions in human and mice. Irrespective of sex, deletion of Fn-EDA reduces early atherosclerosis in apolipoprotein E-deficient (Apoe-/-) mice. However, the contribution of Fn-EDA in advanced atherosclerosis remains poorly characterized. We determined the contribution of Fn-EDA in advanced atherosclerotic lesions of aged (1-year-old) Apoe-/- mice.Approach and resultsPlaque composition was determined in the innominate artery, a plaque instability site that is known to mimic several histological features of vulnerable human plaques. Female Apoe-/-, Fn-EDA-/-Apoe-/-, TLR4-/-Apoe-/-, and Fn-EDA-/-TLR4-/-Apoe-/- mice were fed a high-fat Western diet for 44 weeks. Fn-EDA-/-Apoe-/- mice exhibited reduced plaque size characterized by smaller necrotic cores, thick fibrous caps containing abundant vascular smooth muscle cells and collagen, reduced CD68/MMP9 (matrix metalloproteinase 9)-positive content, less accumulation of MMP-cleaved extracellular matrix aggrecan, and decreased vascular smooth muscle cell and macrophage apoptosis (P<0.05 versus Apoe-/- mice). Together these findings suggest that Fn-EDA induces plaque destabilization. Deletion of TLR4 reduced histological features of plaque instability in Apoe-/- mice but did not further reduce features of plaque destabilization in Fn-EDA-/-Apoe-/- mice, suggesting that TLR4 may contribute to Fn-EDA-induced plaque destabilization. Fn-EDA potentiated TLR4-dependent MMP9 expression in bone marrow-derived macrophages, suggesting that macrophage TLR4 may contribute to Fn-EDA-mediated plaque instability.ConclusionsFn-EDA induces histological features of plaque instability in established lesions of aged Apoe-/- mice. The abundance of Fn-EDA in advanced atherosclerotic lesions may increase the risk of plaque destabilization."xsd:string |
| http://purl.uniprot.org/citations/29326316 | http://purl.org/dc/terms/identifier | "doi:10.1161/atvbaha.117.310345"xsd:string |
| http://purl.uniprot.org/citations/29326316 | http://purl.uniprot.org/core/author | "Jain M."xsd:string |
| http://purl.uniprot.org/citations/29326316 | http://purl.uniprot.org/core/author | "Lentz S.R."xsd:string |
| http://purl.uniprot.org/citations/29326316 | http://purl.uniprot.org/core/author | "Chauhan A.K."xsd:string |
| http://purl.uniprot.org/citations/29326316 | http://purl.uniprot.org/core/author | "Doddapattar P."xsd:string |
| http://purl.uniprot.org/citations/29326316 | http://purl.uniprot.org/core/author | "Dhanesha N."xsd:string |
| http://purl.uniprot.org/citations/29326316 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29326316 | http://purl.uniprot.org/core/name | "Arterioscler Thromb Vasc Biol"xsd:string |
| http://purl.uniprot.org/citations/29326316 | http://purl.uniprot.org/core/pages | "500-508"xsd:string |
| http://purl.uniprot.org/citations/29326316 | http://purl.uniprot.org/core/title | "Fibronectin Containing Extra Domain A Induces Plaque Destabilization in the Innominate Artery of Aged Apolipoprotein E-Deficient Mice."xsd:string |
| http://purl.uniprot.org/citations/29326316 | http://purl.uniprot.org/core/volume | "38"xsd:string |
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