| http://purl.uniprot.org/citations/29331676 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29331676 | http://www.w3.org/2000/01/rdf-schema#comment | "The influenza A virus protein PA-X comprises an N-terminal PA region and a C-terminal PA-X-specific region. PA-X suppresses host gene expression, termed shutoff, via mRNA cleavage. Although the endonuclease active site in the N-terminal PA region of PA-X and basic amino acids in the C-terminal PA-X-specific region are known to be important for PA-X shutoff activity, other amino acids may also play a role. Here, we used yeast to identify novel amino acids of PA-X that are important for PA-X shutoff activity. Unlike wild-type PA-X, most PA-X mutants predominantly localized in the cytoplasm, indicating that these mutations decreased the shutoff activity of PA-X by affecting PA-X translocation to the nucleus. Mapping of the identified amino acids onto the N-terminal structure of PA revealed that some of them likely contribute to the formation of the endonuclease active site of PA."xsd:string |
| http://purl.uniprot.org/citations/29331676 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.virol.2018.01.004"xsd:string |
| http://purl.uniprot.org/citations/29331676 | http://purl.uniprot.org/core/author | "Oishi K."xsd:string |
| http://purl.uniprot.org/citations/29331676 | http://purl.uniprot.org/core/author | "Kawaoka Y."xsd:string |
| http://purl.uniprot.org/citations/29331676 | http://purl.uniprot.org/core/author | "Yamayoshi S."xsd:string |
| http://purl.uniprot.org/citations/29331676 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29331676 | http://purl.uniprot.org/core/name | "Virology"xsd:string |
| http://purl.uniprot.org/citations/29331676 | http://purl.uniprot.org/core/pages | "71-75"xsd:string |
| http://purl.uniprot.org/citations/29331676 | http://purl.uniprot.org/core/title | "Identification of novel amino acid residues of influenza virus PA-X that are important for PA-X shutoff activity by using yeast."xsd:string |
| http://purl.uniprot.org/citations/29331676 | http://purl.uniprot.org/core/volume | "516"xsd:string |
| http://purl.uniprot.org/citations/29331676 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29331676 |
| http://purl.uniprot.org/citations/29331676 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29331676 |
| http://purl.uniprot.org/uniprot/#_P03433-mappedCitation-29331676 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29331676 |
| http://purl.uniprot.org/uniprot/P03433 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/29331676 |