| http://purl.uniprot.org/citations/29335408 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29335408 | http://www.w3.org/2000/01/rdf-schema#comment | "Whether hematopoietic cell-restricted distribution of antigens affects the degree of thymic negative selection has not been investigated in detail. Here, we show that T cells specific for hematopoietic cell-restricted antigens (HRA) are not completely deleted in the thymus, using the mouse minor histocompatibility antigen H60, the expression of which is restricted to hematopoietic cells. As a result, low avidity T cells escape from thymic deletion. This incomplete thymic deletion occurs to the T cells developing de novo in the thymus of H60-positive recipients in H60-mismatched bone marrow transplantation (BMT). H60-specific thymic deletion escapee CD8+ T cells exhibit effector differentiation potentials in the periphery and contribute to graft-versus-leukemia effects in the recipients of H60-mismatched BMT, regressing H60+ hematological tumors. These results provide information essential for understanding thymic negative selection and developing a strategy to treat hematological tumors."xsd:string |
| http://purl.uniprot.org/citations/29335408 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-017-02665-z"xsd:string |
| http://purl.uniprot.org/citations/29335408 | http://purl.uniprot.org/core/author | "Chang J."xsd:string |
| http://purl.uniprot.org/citations/29335408 | http://purl.uniprot.org/core/author | "Lee D.S."xsd:string |
| http://purl.uniprot.org/citations/29335408 | http://purl.uniprot.org/core/author | "Kim W."xsd:string |
| http://purl.uniprot.org/citations/29335408 | http://purl.uniprot.org/core/author | "Lee S.H."xsd:string |
| http://purl.uniprot.org/citations/29335408 | http://purl.uniprot.org/core/author | "Kim J.Y."xsd:string |
| http://purl.uniprot.org/citations/29335408 | http://purl.uniprot.org/core/author | "Oh S."xsd:string |
| http://purl.uniprot.org/citations/29335408 | http://purl.uniprot.org/core/author | "Kim M.G."xsd:string |
| http://purl.uniprot.org/citations/29335408 | http://purl.uniprot.org/core/author | "Min C.K."xsd:string |
| http://purl.uniprot.org/citations/29335408 | http://purl.uniprot.org/core/author | "Choi K."xsd:string |
| http://purl.uniprot.org/citations/29335408 | http://purl.uniprot.org/core/author | "Choi E.Y."xsd:string |
| http://purl.uniprot.org/citations/29335408 | http://purl.uniprot.org/core/author | "Kim H.D."xsd:string |
| http://purl.uniprot.org/citations/29335408 | http://purl.uniprot.org/core/author | "Park G.S."xsd:string |
| http://purl.uniprot.org/citations/29335408 | http://purl.uniprot.org/core/author | "Nam G."xsd:string |
| http://purl.uniprot.org/citations/29335408 | http://purl.uniprot.org/core/author | "Jung M.H."xsd:string |
| http://purl.uniprot.org/citations/29335408 | http://purl.uniprot.org/core/author | "Ju J.M."xsd:string |
| http://purl.uniprot.org/citations/29335408 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29335408 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/29335408 | http://purl.uniprot.org/core/pages | "225"xsd:string |
| http://purl.uniprot.org/citations/29335408 | http://purl.uniprot.org/core/title | "Escape from thymic deletion and anti-leukemic effects of T cells specific for hematopoietic cell-restricted antigen."xsd:string |
| http://purl.uniprot.org/citations/29335408 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/29335408 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29335408 |
| http://purl.uniprot.org/citations/29335408 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29335408 |