| http://purl.uniprot.org/citations/29335463 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29335463 | http://www.w3.org/2000/01/rdf-schema#comment | "Topologically associating domains (TADs) are fundamental elements of the eukaryotic genomic structure. However, recent studies suggest that the insulating complexes, CTCF/cohesin, present at TAD borders in mammals are absent from those in Drosophila melanogaster, raising the possibility that border elements are not conserved among metazoans. Using in situ Hi-C with sub-kb resolution, here we show that the D. melanogaster genome is almost completely partitioned into >4000 TADs, nearly sevenfold more than previously identified. The overwhelming majority of these TADs are demarcated by the insulator complexes, BEAF-32/CP190, or BEAF-32/Chromator, indicating that these proteins may play an analogous role in flies as that of CTCF/cohesin in mammals. Moreover, extended regions previously thought to be unstructured are shown to consist of small contiguous TADs, a property also observed in mammals upon re-examination. Altogether, our work demonstrates that fundamental features associated with the higher-order folding of the genome are conserved from insects to mammals."xsd:string |
| http://purl.uniprot.org/citations/29335463 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-017-02526-9"xsd:string |
| http://purl.uniprot.org/citations/29335463 | http://purl.uniprot.org/core/author | "Sun Q."xsd:string |
| http://purl.uniprot.org/citations/29335463 | http://purl.uniprot.org/core/author | "Shao Z."xsd:string |
| http://purl.uniprot.org/citations/29335463 | http://purl.uniprot.org/core/author | "Wang Q."xsd:string |
| http://purl.uniprot.org/citations/29335463 | http://purl.uniprot.org/core/author | "Czajkowsky D.M."xsd:string |
| http://purl.uniprot.org/citations/29335463 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29335463 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/29335463 | http://purl.uniprot.org/core/pages | "188"xsd:string |
| http://purl.uniprot.org/citations/29335463 | http://purl.uniprot.org/core/title | "Sub-kb Hi-C in D. melanogaster reveals conserved characteristics of TADs between insect and mammalian cells."xsd:string |
| http://purl.uniprot.org/citations/29335463 | http://purl.uniprot.org/core/volume | "9"xsd:string |
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| http://purl.uniprot.org/uniprot/#_Q24478-mappedCitation-29335463 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29335463 |