| http://purl.uniprot.org/citations/29335601 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29335601 | http://www.w3.org/2000/01/rdf-schema#comment | "The TLR4 co-receptor CD14 was identified as an IBD candidate gene. Here, its influence on the intestinal barrier was addressed utilizing E. coli Nissle (EcN), which induces severe inflammation in germfree TLR4-/- mice. After monoassociation, EcN was detected in spleens and livers of TLR4-/- and CD14-/- but not wildtype mice. Barrier impairment was characterized by increased apoptosis and decreased epithelial junction (EJ) expression and was reversed by TLR2 stimulation in CD14-/- mice. Bone marrow (BM) transplantation revealed contribution of hematopoietic and non-hematopoietic cells towards intestinal homeostasis. EcN inoculated WT mice showed B cell activation, CD14-/- and TLR4-/- mice cytotoxic T cell and impaired B cell responses. The latter was characterized by absence of B cells in TLR4-/- mice, decreased levels of EcN induced immunoglobulins and downregulation of their transporter pIgR. EcN colonization of mice with genetically or antibody induced impaired B cell response resulted in dissemination of EcN and downregulation of EJ. BM chimeras indicated that CD14 originating from radiation resistant cells is sufficient to restore EJ-function. Overall, CD14/TLR4 signalling seems to be critical for intestinal barrier function and for the crosstalk between B cells and the epithelium, underlining that CD14 serves as a protective modulator of intestinal homeostasis."xsd:string |
| http://purl.uniprot.org/citations/29335601 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-017-19062-7"xsd:string |
| http://purl.uniprot.org/citations/29335601 | http://purl.uniprot.org/core/author | "Buettner M."xsd:string |
| http://purl.uniprot.org/citations/29335601 | http://purl.uniprot.org/core/author | "Bleich A."xsd:string |
| http://purl.uniprot.org/citations/29335601 | http://purl.uniprot.org/core/author | "Basic M."xsd:string |
| http://purl.uniprot.org/citations/29335601 | http://purl.uniprot.org/core/author | "Smoczek A."xsd:string |
| http://purl.uniprot.org/citations/29335601 | http://purl.uniprot.org/core/author | "Buchheister S."xsd:string |
| http://purl.uniprot.org/citations/29335601 | http://purl.uniprot.org/core/author | "Keubler L.M."xsd:string |
| http://purl.uniprot.org/citations/29335601 | http://purl.uniprot.org/core/author | "Bruesch I."xsd:string |
| http://purl.uniprot.org/citations/29335601 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29335601 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/29335601 | http://purl.uniprot.org/core/pages | "719"xsd:string |
| http://purl.uniprot.org/citations/29335601 | http://purl.uniprot.org/core/title | "Loss of CD14 leads to disturbed epithelial-B cell crosstalk and impairment of the intestinal barrier after E. coli Nissle monoassociation."xsd:string |
| http://purl.uniprot.org/citations/29335601 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/29335601 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29335601 |
| http://purl.uniprot.org/citations/29335601 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29335601 |
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| http://purl.uniprot.org/uniprot/#_A2BHU8-mappedCitation-29335601 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29335601 |
| http://purl.uniprot.org/uniprot/#_L0CL36-mappedCitation-29335601 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29335601 |
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| http://purl.uniprot.org/uniprot/#_L0CMZ8-mappedCitation-29335601 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29335601 |
| http://purl.uniprot.org/uniprot/#_P10810-mappedCitation-29335601 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29335601 |
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| http://purl.uniprot.org/uniprot/#_P47774-mappedCitation-29335601 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29335601 |