| http://purl.uniprot.org/citations/29335647 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29335647 | http://www.w3.org/2000/01/rdf-schema#comment | "Pulmonary immunity requires tight regulation, as interstitial inflammation can compromise gas exchange and lead to respiratory failure. Here we found a greater number of aged CD11bhiL-selectinloCXCR4+ polymorphonuclear leukocytes (PMNs) in lung vasculature than in the peripheral circulation. Using pulmonary intravital microscopy, we observed lung PMNs physically interacting with B cells via β2 integrins; this initiated neutrophil apoptosis, which led to macrophage-mediated clearance. Genetic deletion of B cells led to the accumulation of aged PMNs in the lungs without systemic inflammation, which caused pathological fibrotic interstitial lung disease that was attenuated by the adoptive transfer of B cells or depletion of PMNs. Thus, the lungs are an intermediary niche in the PMN lifecycle wherein aged PMNs are regulated by B cells, which restrains their potential to cause pulmonary pathology."xsd:string |
| http://purl.uniprot.org/citations/29335647 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41590-017-0030-x"xsd:string |
| http://purl.uniprot.org/citations/29335647 | http://purl.uniprot.org/core/author | "Kim J.H."xsd:string |
| http://purl.uniprot.org/citations/29335647 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/29335647 | http://purl.uniprot.org/core/author | "Lou Y."xsd:string |
| http://purl.uniprot.org/citations/29335647 | http://purl.uniprot.org/core/author | "Kelly M.M."xsd:string |
| http://purl.uniprot.org/citations/29335647 | http://purl.uniprot.org/core/author | "Petri B."xsd:string |
| http://purl.uniprot.org/citations/29335647 | http://purl.uniprot.org/core/author | "Jirik F.R."xsd:string |
| http://purl.uniprot.org/citations/29335647 | http://purl.uniprot.org/core/author | "Yipp B.G."xsd:string |
| http://purl.uniprot.org/citations/29335647 | http://purl.uniprot.org/core/author | "Divangahi M."xsd:string |
| http://purl.uniprot.org/citations/29335647 | http://purl.uniprot.org/core/author | "Lee E.K.S."xsd:string |
| http://purl.uniprot.org/citations/29335647 | http://purl.uniprot.org/core/author | "Podstawka J."xsd:string |
| http://purl.uniprot.org/citations/29335647 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29335647 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
| http://purl.uniprot.org/citations/29335647 | http://purl.uniprot.org/core/pages | "192-201"xsd:string |
| http://purl.uniprot.org/citations/29335647 | http://purl.uniprot.org/core/title | "Aged polymorphonuclear leukocytes cause fibrotic interstitial lung disease in the absence of regulation by B cells."xsd:string |
| http://purl.uniprot.org/citations/29335647 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/29335647 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29335647 |
| http://purl.uniprot.org/citations/29335647 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29335647 |
| http://purl.uniprot.org/uniprot/#_A0A075B5P6-mappedCitation-29335647 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29335647 |
| http://purl.uniprot.org/uniprot/#_A0A075B6A0-mappedCitation-29335647 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29335647 |
| http://purl.uniprot.org/uniprot/#_A0A0X1KG58-mappedCitation-29335647 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29335647 |
| http://purl.uniprot.org/uniprot/#_Q3U1A5-mappedCitation-29335647 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29335647 |
| http://purl.uniprot.org/uniprot/#_P15919-mappedCitation-29335647 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29335647 |