DESCRIBE <http://purl.uniprot.org/citations/29338302>

Subject	Predicate	Object
http://purl.uniprot.org/citations/29338302	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/29338302	http://www.w3.org/2000/01/rdf-schema#comment	" Background/rationale Experimental studies support the role of neurotransmitter genes in dementia risk, but human studies utilizing single variants in candidate genes have had limited success. Methods We used the gene-based testing program Versatile Gene-based Association Study to assess whether aggregate variation across 6 neurotransmitter pathways influences risk of cognitive decline in 8159 cognitively normal elderly (≥65 years old) adults from 3 community-based cohorts. Results Common genetic variation in GNG4 and KCNQ2 was associated with cognitive decline. In human brain tissue data sets, both GNG4 and KCNQ2 show higher expression in hippocampus relative to other brain regions; GNG4 expression decreases with advancing age. Both GNG4 and KCNQ2 show highest expression in fetal astrocytes. Conclusion Genetic variation analyses and gene expression data suggest that GNG4 and KCNQ2 may be associated with cognitive decline in normal aging. Gene-based testing of neurotransmitter pathways may confirm and reveal novel risk genes in future studies of healthy cognitive aging."xsd:string
http://purl.uniprot.org/citations/29338302	http://purl.org/dc/terms/identifier	"doi:10.1177/1533317517739384"xsd:string
http://purl.uniprot.org/citations/29338302	http://purl.uniprot.org/core/author	"Liu Y."xsd:string
http://purl.uniprot.org/citations/29338302	http://purl.uniprot.org/core/author	"Bonham L.W."xsd:string
http://purl.uniprot.org/citations/29338302	http://purl.uniprot.org/core/author	"Yokoyama J.S."xsd:string
http://purl.uniprot.org/citations/29338302	http://purl.uniprot.org/core/author	"Yaffe K."xsd:string
http://purl.uniprot.org/citations/29338302	http://purl.uniprot.org/core/author	"Cummings S.R."xsd:string
http://purl.uniprot.org/citations/29338302	http://purl.uniprot.org/core/author	"Evans D.S."xsd:string
http://purl.uniprot.org/citations/29338302	http://purl.uniprot.org/core/date	"2018"xsd:gYear
http://purl.uniprot.org/citations/29338302	http://purl.uniprot.org/core/name	"Am J Alzheimers Dis Other Demen"xsd:string
http://purl.uniprot.org/citations/29338302	http://purl.uniprot.org/core/pages	"153-165"xsd:string
http://purl.uniprot.org/citations/29338302	http://purl.uniprot.org/core/title	"Neurotransmitter Pathway Genes in Cognitive Decline During Aging: Evidence for GNG4 and KCNQ2 Genes."xsd:string
http://purl.uniprot.org/citations/29338302	http://purl.uniprot.org/core/volume	"33"xsd:string
http://purl.uniprot.org/citations/29338302	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/29338302
http://purl.uniprot.org/citations/29338302	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/29338302
http://purl.uniprot.org/uniprot/#_B1APZ0-mappedCitation-29338302	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/29338302
http://purl.uniprot.org/uniprot/#_B4DEP4-mappedCitation-29338302	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/29338302
http://purl.uniprot.org/uniprot/#_P50150-mappedCitation-29338302	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/29338302
http://purl.uniprot.org/uniprot/#_O43526-mappedCitation-29338302	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/29338302
http://purl.uniprot.org/uniprot/#_Q53Y30-mappedCitation-29338302	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/29338302
http://purl.uniprot.org/uniprot/#_Q6UXV8-mappedCitation-29338302	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/29338302
http://purl.uniprot.org/uniprot/Q53Y30	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/29338302
http://purl.uniprot.org/uniprot/B1APZ0	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/29338302
http://purl.uniprot.org/uniprot/P50150	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/29338302