| http://purl.uniprot.org/citations/29339121 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29339121 | http://www.w3.org/2000/01/rdf-schema#comment | "Arg Kinase-binding protein 2 (ArgBP2) is considered to be a scaffold protein that coordinates multiple signaling pathways converging on cell adhesion and actin cytoskeletal organization. It also plays an important role in blocking cancer metastasis as a potential tumor suppressor. However, its regulation mechanisms in tumor migration, especially in gastric cancer, are not fully understood. Here, we identified an ArgBP2 enhancer and showed that heat shock factor 1 (HSF1) directly interacted with microrchidia CW-type zinc finger 2 (MORC2) and bound to the enhancer of ArgBP2. HSF1 was found to promote proliferation, migration and invasion of gastric cancer cells. HSF1 or/and MORC2 increased recruitment of the polycomb repressive complex 2 (PRC2), particularly enhancer of zeste homolog 2 (EZH2), to the ArgBP2 enhancer and catalyzed tri-methylation of lysine 27 on histone H3 (H3K27me3), leading to transcriptional repression of ArgBP2. In addition, HSF1 and MORC2-induced migration and invasion in gastric cancer cells was dependent on ArgBP2 or EZH2. Clinical data exhibited a negative correlation of ArgBP2 with MORC2, HSF1, and EZH2. Our results thus contribute to the knowledge of the regulatory mechanism of HSF1 in down-regulating ArgBP2, providing new insight into the HSF1&MORC2-PRC2-ArgBP2 signaling pathway and a better understanding of their functions in gastric cancer cells."xsd:string |
| http://purl.uniprot.org/citations/29339121 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbadis.2018.01.011"xsd:string |
| http://purl.uniprot.org/citations/29339121 | http://purl.uniprot.org/core/author | "Li F."xsd:string |
| http://purl.uniprot.org/citations/29339121 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/29339121 | http://purl.uniprot.org/core/author | "Liu F."xsd:string |
| http://purl.uniprot.org/citations/29339121 | http://purl.uniprot.org/core/author | "Gu H."xsd:string |
| http://purl.uniprot.org/citations/29339121 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/29339121 | http://purl.uniprot.org/core/author | "Tong Y."xsd:string |
| http://purl.uniprot.org/citations/29339121 | http://purl.uniprot.org/core/author | "Shao Y."xsd:string |
| http://purl.uniprot.org/citations/29339121 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29339121 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta Mol Basis Dis"xsd:string |
| http://purl.uniprot.org/citations/29339121 | http://purl.uniprot.org/core/pages | "1104-1114"xsd:string |
| http://purl.uniprot.org/citations/29339121 | http://purl.uniprot.org/core/title | "HSF1, in association with MORC2, downregulates ArgBP2 via the PRC2 family in gastric cancer cells."xsd:string |
| http://purl.uniprot.org/citations/29339121 | http://purl.uniprot.org/core/volume | "1864"xsd:string |
| http://purl.uniprot.org/citations/29339121 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29339121 |
| http://purl.uniprot.org/citations/29339121 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29339121 |
| http://purl.uniprot.org/uniprot/#_A0A8Q3WKF2-mappedCitation-29339121 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29339121 |
| http://purl.uniprot.org/uniprot/#_B3KNQ9-mappedCitation-29339121 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29339121 |
| http://purl.uniprot.org/uniprot/#_B2R7H6-mappedCitation-29339121 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29339121 |
| http://purl.uniprot.org/uniprot/#_B4DTG4-mappedCitation-29339121 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29339121 |
| http://purl.uniprot.org/uniprot/#_B7Z997-mappedCitation-29339121 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29339121 |
| http://purl.uniprot.org/uniprot/#_B3KPU4-mappedCitation-29339121 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29339121 |
| http://purl.uniprot.org/uniprot/#_B3KWP0-mappedCitation-29339121 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29339121 |
| http://purl.uniprot.org/uniprot/#_B7Z3D7-mappedCitation-29339121 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29339121 |