| http://purl.uniprot.org/citations/29343444 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29343444 | http://www.w3.org/2000/01/rdf-schema#comment | "CD103+ dendritic cells are critical for cross-presentation of tumor antigens. Here we have shown that during immunotherapy, large numbers of cells expressing CD103 arose in murine tumors via direct differentiation of Ly6c+ monocytic precursors. These Ly6c+CD103+ cells could derive from bone-marrow monocytic progenitors (cMoPs) or from peripheral cells present within the myeloid-derived suppressor cell (MDSC) population. Differentiation was controlled by inflammation-induced activation of the transcription factor p53, which drove upregulation of Batf3 and acquisition of the Ly6c+CD103+ phenotype. Mice with a targeted deletion of p53 in myeloid cells selectively lost the Ly6c+CD103+ population and became unable to respond to multiple forms of immunotherapy and immunogenic chemotherapy. Conversely, increasing p53 expression using a p53-agonist drug caused a sustained increase in Ly6c+CD103+ cells in tumors during immunotherapy, which markedly enhanced the efficacy and duration of response. Thus, p53-driven differentiation of Ly6c+CD103+ monocytic cells represents a potent and previously unrecognized target for immunotherapy."xsd:string |
| http://purl.uniprot.org/citations/29343444 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2017.12.014"xsd:string |
| http://purl.uniprot.org/citations/29343444 | http://purl.uniprot.org/core/author | "He Y."xsd:string |
| http://purl.uniprot.org/citations/29343444 | http://purl.uniprot.org/core/author | "Lee E.J."xsd:string |
| http://purl.uniprot.org/citations/29343444 | http://purl.uniprot.org/core/author | "Shi H."xsd:string |
| http://purl.uniprot.org/citations/29343444 | http://purl.uniprot.org/core/author | "Xu H."xsd:string |
| http://purl.uniprot.org/citations/29343444 | http://purl.uniprot.org/core/author | "Guo G."xsd:string |
| http://purl.uniprot.org/citations/29343444 | http://purl.uniprot.org/core/author | "Cui Y."xsd:string |
| http://purl.uniprot.org/citations/29343444 | http://purl.uniprot.org/core/author | "Shimoda M."xsd:string |
| http://purl.uniprot.org/citations/29343444 | http://purl.uniprot.org/core/author | "Rodriguez P.C."xsd:string |
| http://purl.uniprot.org/citations/29343444 | http://purl.uniprot.org/core/author | "Baban B."xsd:string |
| http://purl.uniprot.org/citations/29343444 | http://purl.uniprot.org/core/author | "Blazar B.R."xsd:string |
| http://purl.uniprot.org/citations/29343444 | http://purl.uniprot.org/core/author | "Munn D.H."xsd:string |
| http://purl.uniprot.org/citations/29343444 | http://purl.uniprot.org/core/author | "Wolchok J.D."xsd:string |
| http://purl.uniprot.org/citations/29343444 | http://purl.uniprot.org/core/author | "Johnson T.S."xsd:string |
| http://purl.uniprot.org/citations/29343444 | http://purl.uniprot.org/core/author | "Sharma M.D."xsd:string |
| http://purl.uniprot.org/citations/29343444 | http://purl.uniprot.org/core/author | "Pacholczyk R."xsd:string |
| http://purl.uniprot.org/citations/29343444 | http://purl.uniprot.org/core/author | "Bronte V."xsd:string |
| http://purl.uniprot.org/citations/29343444 | http://purl.uniprot.org/core/author | "Koehn B.H."xsd:string |
| http://purl.uniprot.org/citations/29343444 | http://purl.uniprot.org/core/author | "Venable C."xsd:string |
| http://purl.uniprot.org/citations/29343444 | http://purl.uniprot.org/core/author | "Mergoub T."xsd:string |
| http://purl.uniprot.org/citations/29343444 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29343444 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/29343444 | http://purl.uniprot.org/core/pages | "91-106.e6"xsd:string |