| http://purl.uniprot.org/citations/29343764 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29343764 | http://www.w3.org/2000/01/rdf-schema#comment | "Vitamin D is a steroid hormone precursor that is associated with a range of human traits and diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four genome-wide significant loci (GC, NADSYN1/DHCR7, CYP2R1, CYP24A1). In this study, we expand the previous SUNLIGHT Consortium GWAS discovery sample size from 16,125 to 79,366 (all European descent). This larger GWAS yields two additional loci harboring genome-wide significant variants (P = 4.7×10-9 at rs8018720 in SEC23A, and P = 1.9×10-14 at rs10745742 in AMDHD1). The overall estimate of heritability of 25-hydroxyvitamin D serum concentrations attributable to GWAS common SNPs is 7.5%, with statistically significant loci explaining 38% of this total. Further investigation identifies signal enrichment in immune and hematopoietic tissues, and clustering with autoimmune diseases in cell-type-specific analysis. Larger studies are required to identify additional common SNPs, and to explore the role of rare or structural variants and gene-gene interactions in the heritability of circulating 25-hydroxyvitamin D levels."xsd:string |
| http://purl.uniprot.org/citations/29343764 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-017-02662-2"xsd:string |
| http://purl.uniprot.org/citations/29343764 | http://purl.uniprot.org/core/author | "Jiang X."xsd:string |
| http://purl.uniprot.org/citations/29343764 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/29343764 | http://purl.uniprot.org/core/author | "Tang W."xsd:string |
| http://purl.uniprot.org/citations/29343764 | http://purl.uniprot.org/core/author | "Zhou Y."xsd:string |
| http://purl.uniprot.org/citations/29343764 | http://purl.uniprot.org/core/author | "Zheng J."xsd:string |
| http://purl.uniprot.org/citations/29343764 | http://purl.uniprot.org/core/author | "Spector T."xsd:string |
| http://purl.uniprot.org/citations/29343764 | http://purl.uniprot.org/core/author | "Liu C.T."xsd:string |
| http://purl.uniprot.org/citations/29343764 | http://purl.uniprot.org/core/author | "Rotter J.I."xsd:string |
| http://purl.uniprot.org/citations/29343764 | http://purl.uniprot.org/core/author | "Zhou A."xsd:string |
| http://purl.uniprot.org/citations/29343764 | http://purl.uniprot.org/core/author | "Kraft P."xsd:string |
| http://purl.uniprot.org/citations/29343764 | http://purl.uniprot.org/core/author | "Danesh J."xsd:string |
| http://purl.uniprot.org/citations/29343764 | http://purl.uniprot.org/core/author | "Dupuis J."xsd:string |
| http://purl.uniprot.org/citations/29343764 | http://purl.uniprot.org/core/author | "Jukema J.W."xsd:string |
| http://purl.uniprot.org/citations/29343764 | http://purl.uniprot.org/core/author | "McCarthy M.I."xsd:string |
| http://purl.uniprot.org/citations/29343764 | http://purl.uniprot.org/core/author | "Campbell H."xsd:string |
| http://purl.uniprot.org/citations/29343764 | http://purl.uniprot.org/core/author | "Hayward C."xsd:string |
| http://purl.uniprot.org/citations/29343764 | http://purl.uniprot.org/core/author | "Wilson J.F."xsd:string |
| http://purl.uniprot.org/citations/29343764 | http://purl.uniprot.org/core/author | "Boerwinkle E."xsd:string |
| http://purl.uniprot.org/citations/29343764 | http://purl.uniprot.org/core/author | "Rivadeneira F."xsd:string |
| http://purl.uniprot.org/citations/29343764 | http://purl.uniprot.org/core/author | "Yao L."xsd:string |
| http://purl.uniprot.org/citations/29343764 | http://purl.uniprot.org/core/author | "Rich S.S."xsd:string |
| http://purl.uniprot.org/citations/29343764 | http://purl.uniprot.org/core/author | "Pilz S."xsd:string |