| http://purl.uniprot.org/citations/29343826 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29343826 | http://www.w3.org/2000/01/rdf-schema#comment | "The mammalian Hippo signaling pathway has been implicated in the self-renewal and differentiation of stem and progenitor cells. MST1 and MST2 (MST1/2) are core serine-threonine kinases in the Hippo signaling pathway, one of which, MST1, has been extensively investigated for its role in T cell and myeloid cell function. These studies have identified MST1 as a promising therapeutic target in immunological disease. However, the roles of MST1/2 in hematopoietic stem cell (HSC) function in vivo are not fully understood. Here, we report that mice with a conditional deletion of Mst1/2 exhibit impaired hematopoietic stem and progenitor cell (HSPC) function under stress condition. Furthermore, Mst1/2 deletion markedly altered mature cell output. Therefore, MST1/2 are indispensable for maintenance as well as function of stem and progenitor cells under steady state conditions and with transplantation stress."xsd:string |
| http://purl.uniprot.org/citations/29343826 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-018-19637-y"xsd:string |
| http://purl.uniprot.org/citations/29343826 | http://purl.uniprot.org/core/author | "Lee D."xsd:string |
| http://purl.uniprot.org/citations/29343826 | http://purl.uniprot.org/core/author | "Lee D.H."xsd:string |
| http://purl.uniprot.org/citations/29343826 | http://purl.uniprot.org/core/author | "Kim T.S."xsd:string |
| http://purl.uniprot.org/citations/29343826 | http://purl.uniprot.org/core/author | "Lim D.S."xsd:string |
| http://purl.uniprot.org/citations/29343826 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29343826 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/29343826 | http://purl.uniprot.org/core/pages | "942"xsd:string |
| http://purl.uniprot.org/citations/29343826 | http://purl.uniprot.org/core/title | "Mammalian sterile 20 kinase 1 and 2 are important regulators of hematopoietic stem cells in stress condition."xsd:string |
| http://purl.uniprot.org/citations/29343826 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/29343826 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29343826 |
| http://purl.uniprot.org/citations/29343826 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29343826 |
| http://purl.uniprot.org/uniprot/#_A2A5M9-mappedCitation-29343826 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29343826 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BQE0-mappedCitation-29343826 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29343826 |
| http://purl.uniprot.org/uniprot/#_F7BYZ4-mappedCitation-29343826 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29343826 |
| http://purl.uniprot.org/uniprot/#_D6RHQ9-mappedCitation-29343826 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29343826 |
| http://purl.uniprot.org/uniprot/#_Q8CDG4-mappedCitation-29343826 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29343826 |
| http://purl.uniprot.org/uniprot/#_Q61156-mappedCitation-29343826 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29343826 |
| http://purl.uniprot.org/uniprot/#_Q9CW82-mappedCitation-29343826 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29343826 |
| http://purl.uniprot.org/uniprot/#_Q9JI10-mappedCitation-29343826 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29343826 |
| http://purl.uniprot.org/uniprot/#_Q9JI11-mappedCitation-29343826 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29343826 |
| http://purl.uniprot.org/uniprot/D6RHQ9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/29343826 |
| http://purl.uniprot.org/uniprot/Q9JI11 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/29343826 |