| http://purl.uniprot.org/citations/29345196 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29345196 | http://www.w3.org/2000/01/rdf-schema#comment | "Surfactant protein C (SPC), a key component of pulmonary surfactant, also plays a role in regulating inflammation. SPC deficiency in patients and mouse models is associated with increased inflammation and delayed repair, but the key drivers of SPC-regulated inflammation in response to injury are largely unknown. This study focuses on a new mechanism of SPC as an anti-inflammatory molecule using SPC-TK/SPC-KO (surfactant protein C-thymidine kinase/surfactant protein C knockout) mice, which represent a novel sterile injury model that mimics clinical acute respiratory distress syndrome (ARDS). SPC-TK mice express the inducible suicide gene thymidine kinase from by the SPC promoter, which targets alveolar type 2 (AT2) cells for depletion in response to ganciclovir (GCV). We compared GCV-induced injury and repair in SPC-TK mice that have normal endogenous SPC expression with SPC-TK/SPC-KO mice lacking SPC expression. In contrast to SPC-TK mice, SPC-TK/SPC-KO mice treated with GCV exhibited more severe inflammation, resulting in over 90% mortality; there was only 8% mortality of SPC-TK animals. SPC-TK/SPC-KO mice had highly elevated inflammatory cytokines and granulocyte infiltration in the bronchoalveolar lavage (BAL) fluid. Consistent with a proinflammatory phenotype, immunofluorescence revealed increased phosphorylated signal transduction and activation of transcription 3 (pSTAT3), suggesting enhanced Janus kinase (JAK)/STAT activation in inflammatory and AT2 cells of SPC-TK/SPC-KO mice. The level of suppressor of cytokine signaling 3, an anti-inflammatory mediator that decreases pSTAT3 signaling, was significantly decreased in the BAL fluid of SPC-TK/SPC-KO mice. Hyperactivation of pSTAT3 and inflammation were rescued by AZD1480, a JAK1/2 inhibitor. Our findings showing a novel role for SPC in regulating inflammation via JAK/STAT may have clinical applications."xsd:string |
| http://purl.uniprot.org/citations/29345196 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajplung.00418.2017"xsd:string |
| http://purl.uniprot.org/citations/29345196 | http://purl.uniprot.org/core/author | "Jin H."xsd:string |
| http://purl.uniprot.org/citations/29345196 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/29345196 | http://purl.uniprot.org/core/author | "Lu Y.C."xsd:string |
| http://purl.uniprot.org/citations/29345196 | http://purl.uniprot.org/core/author | "Lee P.J."xsd:string |
| http://purl.uniprot.org/citations/29345196 | http://purl.uniprot.org/core/author | "Cohn L."xsd:string |
| http://purl.uniprot.org/citations/29345196 | http://purl.uniprot.org/core/author | "Krause D.S."xsd:string |
| http://purl.uniprot.org/citations/29345196 | http://purl.uniprot.org/core/author | "Zeiss C.J."xsd:string |
| http://purl.uniprot.org/citations/29345196 | http://purl.uniprot.org/core/author | "Kaplan A.R."xsd:string |
| http://purl.uniprot.org/citations/29345196 | http://purl.uniprot.org/core/author | "Zhang P.X."xsd:string |
| http://purl.uniprot.org/citations/29345196 | http://purl.uniprot.org/core/author | "Bruscia E.M."xsd:string |
| http://purl.uniprot.org/citations/29345196 | http://purl.uniprot.org/core/author | "Ciechanowicz A.K."xsd:string |
| http://purl.uniprot.org/citations/29345196 | http://purl.uniprot.org/core/author | "Tobin B.A."xsd:string |
| http://purl.uniprot.org/citations/29345196 | http://purl.uniprot.org/core/author | "Tobin R.E."xsd:string |
| http://purl.uniprot.org/citations/29345196 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29345196 | http://purl.uniprot.org/core/name | "Am J Physiol Lung Cell Mol Physiol"xsd:string |
| http://purl.uniprot.org/citations/29345196 | http://purl.uniprot.org/core/pages | "L882-L892"xsd:string |
| http://purl.uniprot.org/citations/29345196 | http://purl.uniprot.org/core/title | "Surfactant protein C dampens inflammation by decreasing JAK/STAT activation during lung repair."xsd:string |
| http://purl.uniprot.org/citations/29345196 | http://purl.uniprot.org/core/volume | "314"xsd:string |
| http://purl.uniprot.org/citations/29345196 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29345196 |
| http://purl.uniprot.org/citations/29345196 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29345196 |
| http://purl.uniprot.org/uniprot/#_B1ASP2-mappedCitation-29345196 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29345196 |
| http://purl.uniprot.org/uniprot/#_B1ASP3-mappedCitation-29345196 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29345196 |