| http://purl.uniprot.org/citations/29348886 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29348886 | http://www.w3.org/2000/01/rdf-schema#comment | "The human fyn-related kinase (FRK) is a non-receptor tyrosine kinase known to have tumor suppressor activity in breast cancer cells. However, its mechanism of action has not been fully characterized. We generated FRK-stable MDA-MB-231 breast cancer cell lines and analyzed the effect on cell proliferation, migration, and invasiveness. We also used kinome analysis to identify potential FRK-regulated signaling pathways. We employed both immunoblotting and RT-PCR to identify/validate FRK-regulated targets (proteins and genes) in these cells. Finally, we interrogated the TCGA and GENT gene expression databases to determine the correlation between the expression of FRK and epithelial/mesenchymal markers. We observed that FRK overexpression suppressed cell proliferation, migration, and invasiveness, inhibited various JAK/STAT, MAPK and Akt signaling pathways, and suppressed the expression of some STAT3 target genes. Also, FRK overexpression increased the expression of epithelial markers including E-cadherin mRNA and down-regulated the transcript levels of vimentin, fibronectin, and slug. Finally, we observed an inverse correlation between FRK expression and mesenchymal markers in a large cohort of breast cancer cells. Our data, therefore, suggests that FRK represses cell proliferation, migration and invasiveness by suppressing epithelial to mesenchymal transition."xsd:string |
| http://purl.uniprot.org/citations/29348886 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.22958"xsd:string |
| http://purl.uniprot.org/citations/29348886 | http://purl.uniprot.org/core/author | "Dai C."xsd:string |
| http://purl.uniprot.org/citations/29348886 | http://purl.uniprot.org/core/author | "Ng C.Y."xsd:string |
| http://purl.uniprot.org/citations/29348886 | http://purl.uniprot.org/core/author | "Chibbar R."xsd:string |
| http://purl.uniprot.org/citations/29348886 | http://purl.uniprot.org/core/author | "Vizeacoumar F."xsd:string |
| http://purl.uniprot.org/citations/29348886 | http://purl.uniprot.org/core/author | "Goel R.K."xsd:string |
| http://purl.uniprot.org/citations/29348886 | http://purl.uniprot.org/core/author | "Lukong K.E."xsd:string |
| http://purl.uniprot.org/citations/29348886 | http://purl.uniprot.org/core/author | "Miah S."xsd:string |
| http://purl.uniprot.org/citations/29348886 | http://purl.uniprot.org/core/author | "Napper S."xsd:string |
| http://purl.uniprot.org/citations/29348886 | http://purl.uniprot.org/core/author | "Bonham K."xsd:string |
| http://purl.uniprot.org/citations/29348886 | http://purl.uniprot.org/core/author | "Raptis L."xsd:string |
| http://purl.uniprot.org/citations/29348886 | http://purl.uniprot.org/core/author | "Bagu E.T."xsd:string |
| http://purl.uniprot.org/citations/29348886 | http://purl.uniprot.org/core/author | "Ogunbolude Y."xsd:string |
| http://purl.uniprot.org/citations/29348886 | http://purl.uniprot.org/core/author | "MacAusland-Berg J."xsd:string |
| http://purl.uniprot.org/citations/29348886 | http://purl.uniprot.org/core/author | "Vizeacoumar F.'"xsd:string |
| http://purl.uniprot.org/citations/29348886 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29348886 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/29348886 | http://purl.uniprot.org/core/pages | "113034-113065"xsd:string |
| http://purl.uniprot.org/citations/29348886 | http://purl.uniprot.org/core/title | "FRK inhibits breast cancer cell migration and invasion by suppressing epithelial-mesenchymal transition."xsd:string |
| http://purl.uniprot.org/citations/29348886 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/29348886 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29348886 |
| http://purl.uniprot.org/citations/29348886 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29348886 |
| http://purl.uniprot.org/uniprot/#_P42685-mappedCitation-29348886 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29348886 |