| http://purl.uniprot.org/citations/29356241 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29356241 | http://www.w3.org/2000/01/rdf-schema#comment | "Follicular dendritic cell-secreted protein (FDC-SP) is a secreted protein expressed in follicular dendritic cells, periodontal ligament and junctional epithelium. To elucidate the transcriptional regulation of the human FDC-SP gene by tumor necrosis factor-α (TNF-α), we conducted real-time PCR, Western blotting, transient transfection analyses with chimeric constructs of the FDC-SP gene promoter linked to a luciferase reporter gene, gel mobility shift and chromatin immunoprecipitation assays using Ca9-22 gingival epithelial cells. TNF-α (10 ng/ml) induced FDC-SP mRNA and protein levels at 3 hr and reached maximum at 12 hr. In transient transfection assays, TNF-α (12 hr) increased the LUC activities of constructs between -116FDCSP and -948FDCSP including the human FDC-SP gene promoter. Transcriptional stimulations by TNF-α were partially inhibited in the -345FDCSP constructs that included 3-bp mutations in the YY1, GATA, CCAAT enhancer-binding protein 2 (C/EBP2) and C/EBP3. Transcriptional activities induced by TNF-α were inhibited by tyrosine kinase, MEK1/2 and phosphoinositide 3-kinase inhibitors. The results of ChIP assays showed that YY1, GATA and C/EBPβ transcription factors interacted with the YY1, GATA, C/EBP2 and C/EBP3 elements that were increased by TNF-α. These studies show that TNF-α stimulates human FDC-SP gene transcription by targeting YY1, GATA, C/EBP2 and C/EBP3 in the FDC-SP gene promoter."xsd:string |
| http://purl.uniprot.org/citations/29356241 | http://purl.org/dc/terms/identifier | "doi:10.1111/gtc.12561"xsd:string |
| http://purl.uniprot.org/citations/29356241 | http://purl.uniprot.org/core/author | "Kato A."xsd:string |
| http://purl.uniprot.org/citations/29356241 | http://purl.uniprot.org/core/author | "Yamazaki M."xsd:string |
| http://purl.uniprot.org/citations/29356241 | http://purl.uniprot.org/core/author | "Nakayama Y."xsd:string |
| http://purl.uniprot.org/citations/29356241 | http://purl.uniprot.org/core/author | "Noda K."xsd:string |
| http://purl.uniprot.org/citations/29356241 | http://purl.uniprot.org/core/author | "Ogata Y."xsd:string |
| http://purl.uniprot.org/citations/29356241 | http://purl.uniprot.org/core/author | "Takai H."xsd:string |
| http://purl.uniprot.org/citations/29356241 | http://purl.uniprot.org/core/author | "Iwai Y."xsd:string |
| http://purl.uniprot.org/citations/29356241 | http://purl.uniprot.org/core/author | "Mezawa M."xsd:string |
| http://purl.uniprot.org/citations/29356241 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29356241 | http://purl.uniprot.org/core/name | "Genes Cells"xsd:string |
| http://purl.uniprot.org/citations/29356241 | http://purl.uniprot.org/core/pages | "161-171"xsd:string |
| http://purl.uniprot.org/citations/29356241 | http://purl.uniprot.org/core/title | "Tumor necrosis factor-alpha regulates human follicular dendritic cell-secreted protein gene transcription in gingival epithelial cells."xsd:string |
| http://purl.uniprot.org/citations/29356241 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/29356241 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29356241 |
| http://purl.uniprot.org/citations/29356241 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29356241 |
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| http://purl.uniprot.org/uniprot/#_A0A411D318-mappedCitation-29356241 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29356241 |
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| http://purl.uniprot.org/uniprot/#_B5BUQ6-mappedCitation-29356241 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29356241 |
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