| http://purl.uniprot.org/citations/29356399 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29356399 | http://www.w3.org/2000/01/rdf-schema#comment | "Understanding the mechanism by which cancer cells enhance stemness facilitates cancer therapies. Here, we revealed that a stem cell transcription factor, SALL4, functions to enhance stemness in basal-like breast cancer cells. We used shRNA-mediated knockdown and gene overexpression systems to analyze gene functions. To evaluate stemness, we performed a sphere formation assay. In SALL4 knockdown cells, the sphere formation ability was reduced, indicating that SALL4 enhances stemness. CD44 is a membrane protein and is known as a stemness factor in cancer. CD44 splicing variants are involved in cancer stemness. We discovered that SALL4 modulates CD44 alternative splicing through the upregulation of KHDRBS3, a splicing factor for CD44. We cloned the KHDRBS3-regulated CD44 splicing isoform (CD44v), which lacks exons 8 and 9. CD44v overexpression prevented a reduction in the sphere formation ability by KHDRBS3 knockdown, indicating that CD44v is positively involved in cancer stemness. In addition, CD44v enhanced anoikis resistance under the control of the SALL4 - KHDRBS3 network. Basal-like breast cancer is an aggressive subtype among breast cancers, and there is no effective therapy so far. Our findings provide molecular targets for basal-like breast cancer therapy. In the future, this study may contribute to the establishment of drugs targeting cancer stemness."xsd:string |
| http://purl.uniprot.org/citations/29356399 | http://purl.org/dc/terms/identifier | "doi:10.1002/cam4.1296"xsd:string |
| http://purl.uniprot.org/citations/29356399 | http://purl.uniprot.org/core/author | "Matsumoto Y."xsd:string |
| http://purl.uniprot.org/citations/29356399 | http://purl.uniprot.org/core/author | "Sato F."xsd:string |
| http://purl.uniprot.org/citations/29356399 | http://purl.uniprot.org/core/author | "Toi M."xsd:string |
| http://purl.uniprot.org/citations/29356399 | http://purl.uniprot.org/core/author | "Itou J."xsd:string |
| http://purl.uniprot.org/citations/29356399 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29356399 | http://purl.uniprot.org/core/name | "Cancer Med"xsd:string |
| http://purl.uniprot.org/citations/29356399 | http://purl.uniprot.org/core/pages | "454-462"xsd:string |
| http://purl.uniprot.org/citations/29356399 | http://purl.uniprot.org/core/title | "SALL4 - KHDRBS3 network enhances stemness by modulating CD44 splicing in basal-like breast cancer."xsd:string |
| http://purl.uniprot.org/citations/29356399 | http://purl.uniprot.org/core/volume | "7"xsd:string |
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