| http://purl.uniprot.org/citations/29358703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29358703 | http://www.w3.org/2000/01/rdf-schema#comment | "Receptor-interacting protein kinase 3 (RIP3)-regulated production of reactive oxygen species (ROS) positively feeds back on tumour necrosis factor (TNF)-induced necroptosis, a type of programmed necrosis. Glutamine catabolism is known to contribute to RIP3-mediated ROS induction, but the major contributor is unknown. Here, we show that RIP3 activates the pyruvate dehydrogenase complex (PDC, also known as PDH), the rate-limiting enzyme linking glycolysis to aerobic respiration, by directly phosphorylating the PDC E3 subunit (PDC-E3) on T135. Upon activation, PDC enhances aerobic respiration and subsequent mitochondrial ROS production. Unexpectedly, mixed-lineage kinase domain-like (MLKL) is also required for the induction of aerobic respiration, and we further show that it is required for RIP3 translocation to meet mitochondria-localized PDC. Our data uncover a regulation mechanism of PDC activity, show that PDC activation by RIP3 is most likely the major mechanism activated by TNF to increase aerobic respiration and its by-product ROS, and suggest that RIP3-dependent induction of aerobic respiration contributes to pathologies related to oxidative stress."xsd:string |
| http://purl.uniprot.org/citations/29358703 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41556-017-0022-y"xsd:string |
| http://purl.uniprot.org/citations/29358703 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/29358703 | http://purl.uniprot.org/core/author | "Han J."xsd:string |
| http://purl.uniprot.org/citations/29358703 | http://purl.uniprot.org/core/author | "He X."xsd:string |
| http://purl.uniprot.org/citations/29358703 | http://purl.uniprot.org/core/author | "Liang Y."xsd:string |
| http://purl.uniprot.org/citations/29358703 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/29358703 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/29358703 | http://purl.uniprot.org/core/author | "Zhao S."xsd:string |
| http://purl.uniprot.org/citations/29358703 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/29358703 | http://purl.uniprot.org/core/author | "Yang Z."xsd:string |
| http://purl.uniprot.org/citations/29358703 | http://purl.uniprot.org/core/author | "Zhou D."xsd:string |
| http://purl.uniprot.org/citations/29358703 | http://purl.uniprot.org/core/author | "Ni H."xsd:string |
| http://purl.uniprot.org/citations/29358703 | http://purl.uniprot.org/core/author | "Zhong C.Q."xsd:string |
| http://purl.uniprot.org/citations/29358703 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29358703 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/29358703 | http://purl.uniprot.org/core/pages | "186-197"xsd:string |
| http://purl.uniprot.org/citations/29358703 | http://purl.uniprot.org/core/title | "RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis."xsd:string |
| http://purl.uniprot.org/citations/29358703 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/29358703 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29358703 |
| http://purl.uniprot.org/citations/29358703 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29358703 |
| http://purl.uniprot.org/uniprot/#_E9PZP3-mappedCitation-29358703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29358703 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BPT3-mappedCitation-29358703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29358703 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BQW9-mappedCitation-29358703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29358703 |