| http://purl.uniprot.org/citations/29368549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29368549 | http://www.w3.org/2000/01/rdf-schema#comment | "Acid (HCl) aspiration during anesthesia may lead to acute lung injury. There is no effective therapy. We hypothesized that HCl instilled intratracheally in C57BL/6 mice results in the formation of low-molecular weight hyaluronan (L-HA), which activates RhoA and Rho kinase (ROCK), causing airway hyperresponsiveness (AHR) and increased permeability. Furthermore, instillation of high-molecular weight hyaluronan (H-HA; Yabro) will reverse lung injury. We instilled HCl in C57BL/6 wild-type (WT), myeloperoxidase gene-deficient (MPO-/-) mice, and CD44 gene-deficient (CD44-/-) mice. WT mice were also instilled intranasally with H-HA (Yabro) at 1 and 23 h post-HCl. All measurements were performed at 1, 5, or 24 h post-HCl. Instillation of HCl in WT but not in CD44-/- resulted in increased inflammation, AHR, lung injury, and L-HA in the bronchoalveolar lavage fluid (BALF) 24 h post-HCl; L-HA levels and lung injury were significantly lower in HCl-instilled MPO-/- mice. Isolated perfused lungs of HCl instilled WT but not of CD44-/- mice had elevated values of the filtration coefficient ( Kf). Addition of L-HA on the apical surface of human primary bronchial epithelial cell monolayer decreased barrier resistance ( RT). H-HA significantly mitigated inflammation, AHR, and pulmonary vascular leakage at 24 h after HCl instillation and mitigated the increase of Kf and RT, as well as ROCK2 phosphorylation. Increased H- and L-HA levels were found in the BALF of mechanically ventilated patients but not in healthy volunteers. HCl instillation-induced lung injury is mediated by the L-HA-CD44-RhoA-ROCK2 signaling pathway, and H-HA is a potential novel therapeutic agent for acid aspiration-induced lung injury."xsd:string |
| http://purl.uniprot.org/citations/29368549 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajplung.00510.2017"xsd:string |
| http://purl.uniprot.org/citations/29368549 | http://purl.uniprot.org/core/author | "Song W."xsd:string |
| http://purl.uniprot.org/citations/29368549 | http://purl.uniprot.org/core/author | "Yu Z."xsd:string |
| http://purl.uniprot.org/citations/29368549 | http://purl.uniprot.org/core/author | "Ahmad I."xsd:string |
| http://purl.uniprot.org/citations/29368549 | http://purl.uniprot.org/core/author | "Zhou T."xsd:string |
| http://purl.uniprot.org/citations/29368549 | http://purl.uniprot.org/core/author | "Aggarwal S."xsd:string |
| http://purl.uniprot.org/citations/29368549 | http://purl.uniprot.org/core/author | "Pittet J.F."xsd:string |
| http://purl.uniprot.org/citations/29368549 | http://purl.uniprot.org/core/author | "Garantziotis S."xsd:string |
| http://purl.uniprot.org/citations/29368549 | http://purl.uniprot.org/core/author | "Matalon S."xsd:string |
| http://purl.uniprot.org/citations/29368549 | http://purl.uniprot.org/core/author | "Jian M.Y."xsd:string |
| http://purl.uniprot.org/citations/29368549 | http://purl.uniprot.org/core/author | "Trempus C."xsd:string |
| http://purl.uniprot.org/citations/29368549 | http://purl.uniprot.org/core/author | "Wagener B.M."xsd:string |
| http://purl.uniprot.org/citations/29368549 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29368549 | http://purl.uniprot.org/core/name | "Am J Physiol Lung Cell Mol Physiol"xsd:string |
| http://purl.uniprot.org/citations/29368549 | http://purl.uniprot.org/core/pages | "L808-L821"xsd:string |
| http://purl.uniprot.org/citations/29368549 | http://purl.uniprot.org/core/title | "Instillation of hyaluronan reverses acid instillation injury to the mammalian blood gas barrier."xsd:string |
| http://purl.uniprot.org/citations/29368549 | http://purl.uniprot.org/core/volume | "314"xsd:string |
| http://purl.uniprot.org/citations/29368549 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29368549 |
| http://purl.uniprot.org/citations/29368549 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29368549 |
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| http://purl.uniprot.org/uniprot/#_P15379-mappedCitation-29368549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29368549 |
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| http://purl.uniprot.org/uniprot/#_A2APM2-mappedCitation-29368549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29368549 |