| http://purl.uniprot.org/citations/29371428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29371428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29371428 | http://www.w3.org/2000/01/rdf-schema#comment | "Ion channels form the basis for cellular electrical signaling. Despite the scores of genetically identified ion channels selective for other monatomic ions, only one type of proton-selective ion channel has been found in eukaryotic cells. By comparative transcriptome analysis of mouse taste receptor cells, we identified Otopetrin1 (OTOP1), a protein required for development of gravity-sensing otoconia in the vestibular system, as forming a proton-selective ion channel. We found that murine OTOP1 is enriched in acid-detecting taste receptor cells and is required for their zinc-sensitive proton conductance. Two related murine genes, Otop2 and Otop3, and a Drosophila ortholog also encode proton channels. Evolutionary conservation of the gene family and its widespread tissue distribution suggest a broad role for proton channels in physiology and pathophysiology."xsd:string |
| http://purl.uniprot.org/citations/29371428 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.aao3264"xsd:string |
| http://purl.uniprot.org/citations/29371428 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.aao3264"xsd:string |
| http://purl.uniprot.org/citations/29371428 | http://purl.uniprot.org/core/author | "Ye W."xsd:string |
| http://purl.uniprot.org/citations/29371428 | http://purl.uniprot.org/core/author | "Ye W."xsd:string |
| http://purl.uniprot.org/citations/29371428 | http://purl.uniprot.org/core/author | "Smith A.D."xsd:string |
| http://purl.uniprot.org/citations/29371428 | http://purl.uniprot.org/core/author | "Smith A.D."xsd:string |
| http://purl.uniprot.org/citations/29371428 | http://purl.uniprot.org/core/author | "Teng B."xsd:string |
| http://purl.uniprot.org/citations/29371428 | http://purl.uniprot.org/core/author | "Teng B."xsd:string |
| http://purl.uniprot.org/citations/29371428 | http://purl.uniprot.org/core/author | "Cooper A.J."xsd:string |
| http://purl.uniprot.org/citations/29371428 | http://purl.uniprot.org/core/author | "Cooper A.J."xsd:string |
| http://purl.uniprot.org/citations/29371428 | http://purl.uniprot.org/core/author | "Tu Y.H."xsd:string |
| http://purl.uniprot.org/citations/29371428 | http://purl.uniprot.org/core/author | "Tu Y.H."xsd:string |
| http://purl.uniprot.org/citations/29371428 | http://purl.uniprot.org/core/author | "Liman E.R."xsd:string |
| http://purl.uniprot.org/citations/29371428 | http://purl.uniprot.org/core/author | "Liman E.R."xsd:string |
| http://purl.uniprot.org/citations/29371428 | http://purl.uniprot.org/core/author | "Chang R.B."xsd:string |
| http://purl.uniprot.org/citations/29371428 | http://purl.uniprot.org/core/author | "Chang R.B."xsd:string |
| http://purl.uniprot.org/citations/29371428 | http://purl.uniprot.org/core/author | "Artiga D.J."xsd:string |
| http://purl.uniprot.org/citations/29371428 | http://purl.uniprot.org/core/author | "Artiga D.J."xsd:string |
| http://purl.uniprot.org/citations/29371428 | http://purl.uniprot.org/core/author | "Mulhall E.M."xsd:string |
| http://purl.uniprot.org/citations/29371428 | http://purl.uniprot.org/core/author | "Mulhall E.M."xsd:string |
| http://purl.uniprot.org/citations/29371428 | http://purl.uniprot.org/core/author | "Turner H.N."xsd:string |
| http://purl.uniprot.org/citations/29371428 | http://purl.uniprot.org/core/author | "Turner H.N."xsd:string |