| http://purl.uniprot.org/citations/29382851 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29382851 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29382851 | http://www.w3.org/2000/01/rdf-schema#comment | "GTPase of immunity-associated protein 5 (Gimap5) is linked with lymphocyte survival, autoimmunity, and colitis, but its mechanisms of action are unclear. Here, we show that Gimap5 is essential for the inactivation of glycogen synthase kinase-3β (GSK3β) following T cell activation. In the absence of Gimap5, constitutive GSK3β activity constrains c-Myc induction and NFATc1 nuclear import, thereby limiting productive CD4+ T cell proliferation. Additionally, Gimap5 facilitates Ser389 phosphorylation and nuclear translocation of GSK3β, thereby limiting DNA damage in CD4+ T cells. Importantly, pharmacological inhibition and genetic targeting of GSK3β can override Gimap5 deficiency in CD4+ T cells and ameliorates immunopathology in mice. Finally, we show that a human patient with a GIMAP5 loss-of-function mutation has lymphopenia and impaired T cell proliferation in vitro that can be rescued with GSK3 inhibitors. Given that the expression of Gimap5 is lymphocyte-restricted, we propose that its control of GSK3β is an important checkpoint in lymphocyte proliferation."xsd:string |
| http://purl.uniprot.org/citations/29382851 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-018-02897-7"xsd:string |
| http://purl.uniprot.org/citations/29382851 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-018-02897-7"xsd:string |
| http://purl.uniprot.org/citations/29382851 | http://purl.uniprot.org/core/author | "Singh H."xsd:string |
| http://purl.uniprot.org/citations/29382851 | http://purl.uniprot.org/core/author | "Singh H."xsd:string |
| http://purl.uniprot.org/citations/29382851 | http://purl.uniprot.org/core/author | "Woodgett J.R."xsd:string |
| http://purl.uniprot.org/citations/29382851 | http://purl.uniprot.org/core/author | "Woodgett J.R."xsd:string |
| http://purl.uniprot.org/citations/29382851 | http://purl.uniprot.org/core/author | "Hoebe K."xsd:string |
| http://purl.uniprot.org/citations/29382851 | http://purl.uniprot.org/core/author | "Hoebe K."xsd:string |
| http://purl.uniprot.org/citations/29382851 | http://purl.uniprot.org/core/author | "Aksoylar H.I."xsd:string |
| http://purl.uniprot.org/citations/29382851 | http://purl.uniprot.org/core/author | "Aksoylar H.I."xsd:string |
| http://purl.uniprot.org/citations/29382851 | http://purl.uniprot.org/core/author | "Bleesing J."xsd:string |
| http://purl.uniprot.org/citations/29382851 | http://purl.uniprot.org/core/author | "Bleesing J."xsd:string |
| http://purl.uniprot.org/citations/29382851 | http://purl.uniprot.org/core/author | "Endale M."xsd:string |
| http://purl.uniprot.org/citations/29382851 | http://purl.uniprot.org/core/author | "Endale M."xsd:string |
| http://purl.uniprot.org/citations/29382851 | http://purl.uniprot.org/core/author | "Flagg A."xsd:string |
| http://purl.uniprot.org/citations/29382851 | http://purl.uniprot.org/core/author | "Flagg A."xsd:string |
| http://purl.uniprot.org/citations/29382851 | http://purl.uniprot.org/core/author | "Hildeman D."xsd:string |
| http://purl.uniprot.org/citations/29382851 | http://purl.uniprot.org/core/author | "Hildeman D."xsd:string |
| http://purl.uniprot.org/citations/29382851 | http://purl.uniprot.org/core/author | "Jordan M.B."xsd:string |
| http://purl.uniprot.org/citations/29382851 | http://purl.uniprot.org/core/author | "Jordan M.B."xsd:string |
| http://purl.uniprot.org/citations/29382851 | http://purl.uniprot.org/core/author | "Kucuk Z."xsd:string |
| http://purl.uniprot.org/citations/29382851 | http://purl.uniprot.org/core/author | "Kucuk Z."xsd:string |