| http://purl.uniprot.org/citations/29395326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29395326 | http://www.w3.org/2000/01/rdf-schema#comment | "Aberrant activation of innate immune receptors can cause a spectrum of immune disorders, such as Aicardi-Goutières syndrome (AGS). One such receptor is MDA5, a viral dsRNA sensor that induces antiviral immune response. Using a newly developed RNase-protection/RNA-seq approach, we demonstrate here that constitutive activation of MDA5 in AGS results from the loss of tolerance to cellular dsRNAs formed by Alu retroelements. While wild-type MDA5 cannot efficiently recognize Alu-dsRNAs because of its limited filament formation on imperfect duplexes, AGS variants of MDA5 display reduced sensitivity to duplex structural irregularities, assembling signaling-competent filaments on Alu-dsRNAs. Moreover, we identified an unexpected role of an RNA-rich cellular environment in suppressing aberrant MDA5 oligomerization, highlighting context dependence of self versus non-self discrimination. Overall, our work demonstrates that the increased efficiency of MDA5 in recognizing dsRNA comes at a cost of self-recognition and implicates a unique role of Alu-dsRNAs as virus-like elements that shape the primate immune system."xsd:string |
| http://purl.uniprot.org/citations/29395326 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2017.12.016"xsd:string |
| http://purl.uniprot.org/citations/29395326 | http://purl.uniprot.org/core/author | "Yang F."xsd:string |
| http://purl.uniprot.org/citations/29395326 | http://purl.uniprot.org/core/author | "Mu X."xsd:string |
| http://purl.uniprot.org/citations/29395326 | http://purl.uniprot.org/core/author | "Ahmad S."xsd:string |
| http://purl.uniprot.org/citations/29395326 | http://purl.uniprot.org/core/author | "Park J.W."xsd:string |
| http://purl.uniprot.org/citations/29395326 | http://purl.uniprot.org/core/author | "Jacob E."xsd:string |
| http://purl.uniprot.org/citations/29395326 | http://purl.uniprot.org/core/author | "Hur S."xsd:string |
| http://purl.uniprot.org/citations/29395326 | http://purl.uniprot.org/core/author | "Zhang C.Z."xsd:string |
| http://purl.uniprot.org/citations/29395326 | http://purl.uniprot.org/core/author | "Greenwald E."xsd:string |
| http://purl.uniprot.org/citations/29395326 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29395326 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/29395326 | http://purl.uniprot.org/core/pages | "797-810.e13"xsd:string |
| http://purl.uniprot.org/citations/29395326 | http://purl.uniprot.org/core/title | "Breaching Self-Tolerance to Alu Duplex RNA Underlies MDA5-Mediated Inflammation."xsd:string |
| http://purl.uniprot.org/citations/29395326 | http://purl.uniprot.org/core/volume | "172"xsd:string |
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