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http://purl.uniprot.org/citations/29395365http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/29395365http://www.w3.org/2000/01/rdf-schema#comment"

Background

IL-1β-mediated inflammation contributes to development and progression of coronary artery disease (CAD). We aimed to assess the prognostic impact of the inflammatory marker Interleukin-1 receptor antagonist (IL1-Ra), reflecting high IL-1β activity, in patients with documented CAD.

Methods

IL-1Ra levels were determined in 1337 subjects of the AtheroGene study, a prospective cardiovascular registry comprising patients with CAD as detected by coronary angiography presenting with acute coronary syndrome (ACS) or stable angina. Median follow-up was 6.4 years.

Results

Patients with IL1-Ra levels in the highest tertile presented more often with ACS (55% vs. 40% vs. 34%, p < 0.001), were more commonly treated with PCI (47% vs. 39% vs. 34%, p < 0.001), had lower left ventricular ejection fraction (LVEF) (61 ± 15% vs. 62 ± 15% vs. 65 ± 14%, p = 0.001) and higher hs-CRP levels (10.0 vs. 4.2 vs. 2.5 mg/L, p < 0.001). IL1-Ra levels at baseline were predictive for all-cause mortality in the total study cohort after adjustment for conventional cardiovascular risk factors, LVEF, hs-CRP and Troponin T (adjusted HR 1.45 (95% CI 1.16-1.82), p < 0.001). In a subgroup of patients with ACS, but not in those with stable angina, IL1-Ra was an independent predictor for cardiovascular mortality (ACS: adjusted HR 1.93 (95% CI 1.33-2.80), p < 0.001; stable angina: adjusted HR: 1.26 (95% CI 0.92-1.73), p = 0.16).

Conclusion

IL1-Ra is an independent predictor for adverse outcome in patients with documented CAD, beyond the prognostic value of hs-CRP and Troponin T in particular in the setting of ACS. For CAD patients our finding might improve both, risk assessment in secondary prevention and patient selection for anti-inflammatory treatment."xsd:string
http://purl.uniprot.org/citations/29395365http://purl.org/dc/terms/identifier"doi:10.1016/j.ijcard.2018.01.055"xsd:string
http://purl.uniprot.org/citations/29395365http://purl.uniprot.org/core/author"Lackner K.J."xsd:string
http://purl.uniprot.org/citations/29395365http://purl.uniprot.org/core/author"Ludwig S."xsd:string
http://purl.uniprot.org/citations/29395365http://purl.uniprot.org/core/author"Schnabel R."xsd:string
http://purl.uniprot.org/citations/29395365http://purl.uniprot.org/core/author"Blankenberg S."xsd:string
http://purl.uniprot.org/citations/29395365http://purl.uniprot.org/core/author"Zeller T."xsd:string
http://purl.uniprot.org/citations/29395365http://purl.uniprot.org/core/author"Bickel C."xsd:string
http://purl.uniprot.org/citations/29395365http://purl.uniprot.org/core/author"Landmesser U."xsd:string
http://purl.uniprot.org/citations/29395365http://purl.uniprot.org/core/author"Rubsamen N."xsd:string
http://purl.uniprot.org/citations/29395365http://purl.uniprot.org/core/author"Ruprecht H.J."xsd:string
http://purl.uniprot.org/citations/29395365http://purl.uniprot.org/core/author"Schofer N."xsd:string
http://purl.uniprot.org/citations/29395365http://purl.uniprot.org/core/date"2018"xsd:gYear
http://purl.uniprot.org/citations/29395365http://purl.uniprot.org/core/name"Int J Cardiol"xsd:string
http://purl.uniprot.org/citations/29395365http://purl.uniprot.org/core/pages"24-29"xsd:string
http://purl.uniprot.org/citations/29395365http://purl.uniprot.org/core/title"Prognostic impact of Interleukin-1 receptor antagonist in patients with documented coronary artery disease."xsd:string
http://purl.uniprot.org/citations/29395365http://purl.uniprot.org/core/volume"257"xsd:string
http://purl.uniprot.org/citations/29395365http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/29395365
http://purl.uniprot.org/citations/29395365http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/29395365
http://purl.uniprot.org/uniprot/#_P18510-mappedCitation-29395365http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/29395365
http://purl.uniprot.org/uniprot/#_Q9UP87-mappedCitation-29395365http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/29395365
http://purl.uniprot.org/uniprot/Q9UP87http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/29395365
http://purl.uniprot.org/uniprot/P18510http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/29395365