| http://purl.uniprot.org/citations/29395787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29395787 | http://www.w3.org/2000/01/rdf-schema#comment | "Complex I (NADH:ubiquinone oxidoreductase) is central to energy metabolism in mammalian mitochondria. It couples NADH oxidation by ubiquinone to proton transport across the energy-conserving inner membrane, catalyzing respiration and driving ATP synthesis. In the absence of substrates, active complex I gradually enters a pronounced resting or deactive state. The active-deactive transition occurs during ischemia and is crucial for controlling how respiration recovers upon reperfusion. Here, we set a highly active preparation of Bos taurus complex I into the biochemically defined deactive state, and used single-particle electron cryomicroscopy to determine its structure to 4.1 Å resolution. We show that the deactive state arises when critical structural elements that form the ubiquinone-binding site become disordered, and we propose reactivation is induced when substrate binding to the NADH-reduced enzyme templates their reordering. Our structure both rationalizes biochemical data on the deactive state and offers new insights into its physiological and cellular roles."xsd:string |
| http://purl.uniprot.org/citations/29395787 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2017.12.014"xsd:string |
| http://purl.uniprot.org/citations/29395787 | http://purl.uniprot.org/core/author | "Hirst J."xsd:string |
| http://purl.uniprot.org/citations/29395787 | http://purl.uniprot.org/core/author | "Vinothkumar K.R."xsd:string |
| http://purl.uniprot.org/citations/29395787 | http://purl.uniprot.org/core/author | "Blaza J.N."xsd:string |
| http://purl.uniprot.org/citations/29395787 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29395787 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/29395787 | http://purl.uniprot.org/core/pages | "312-319.e3"xsd:string |
| http://purl.uniprot.org/citations/29395787 | http://purl.uniprot.org/core/title | "Structure of the Deactive State of Mammalian Respiratory Complex I."xsd:string |
| http://purl.uniprot.org/citations/29395787 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/29395787 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29395787 |
| http://purl.uniprot.org/citations/29395787 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29395787 |
| http://purl.uniprot.org/uniprot/#_P42026-mappedCitation-29395787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29395787 |
| http://purl.uniprot.org/uniprot/#_P42028-mappedCitation-29395787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29395787 |
| http://purl.uniprot.org/uniprot/#_P42029-mappedCitation-29395787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29395787 |
| http://purl.uniprot.org/uniprot/#_P52505-mappedCitation-29395787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29395787 |
| http://purl.uniprot.org/uniprot/#_O97725-mappedCitation-29395787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29395787 |
| http://purl.uniprot.org/uniprot/#_P23934-mappedCitation-29395787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29395787 |
| http://purl.uniprot.org/uniprot/#_P23935-mappedCitation-29395787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29395787 |
| http://purl.uniprot.org/uniprot/#_P15690-mappedCitation-29395787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29395787 |
| http://purl.uniprot.org/uniprot/#_P25708-mappedCitation-29395787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29395787 |
| http://purl.uniprot.org/uniprot/#_P25712-mappedCitation-29395787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29395787 |
| http://purl.uniprot.org/uniprot/#_P04394-mappedCitation-29395787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29395787 |
| http://purl.uniprot.org/uniprot/#_P03887-mappedCitation-29395787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29395787 |