| http://purl.uniprot.org/citations/29396289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29396289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29396289 | http://www.w3.org/2000/01/rdf-schema#comment | "Val-boroPro (PT-100, Talabostat) induces powerful anti-tumor immune responses in syngeneic cancer models, but its mechanism of action has not yet been established. Val-boroPro is a non-selective inhibitor of post-proline-cleaving serine proteases, and the inhibition of the highly related cytosolic serine proteases Dpp8 and Dpp9 (Dpp8/9) by Val-boroPro was recently demonstrated to trigger an immunostimulatory form of programmed cell death known as pyroptosis selectively in monocytes and macrophages. Here we show that Dpp8/9 inhibition activates the inflammasome sensor protein Nlrp1b, which in turn activates pro-caspase-1 to mediate pyroptosis. This work reveals a previously unrecognized mechanism for activating an innate immune pattern recognition receptor and suggests that Dpp8/9 serve as an intracellular checkpoint to restrain Nlrp1b and the innate immune system."xsd:string |
| http://purl.uniprot.org/citations/29396289 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.chembiol.2017.12.013"xsd:string |
| http://purl.uniprot.org/citations/29396289 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.chembiol.2017.12.013"xsd:string |
| http://purl.uniprot.org/citations/29396289 | http://purl.uniprot.org/core/author | "Johnson D.C."xsd:string |
| http://purl.uniprot.org/citations/29396289 | http://purl.uniprot.org/core/author | "Johnson D.C."xsd:string |
| http://purl.uniprot.org/citations/29396289 | http://purl.uniprot.org/core/author | "Bachovchin D.A."xsd:string |
| http://purl.uniprot.org/citations/29396289 | http://purl.uniprot.org/core/author | "Bachovchin D.A."xsd:string |
| http://purl.uniprot.org/citations/29396289 | http://purl.uniprot.org/core/author | "Chui A.J."xsd:string |
| http://purl.uniprot.org/citations/29396289 | http://purl.uniprot.org/core/author | "Chui A.J."xsd:string |
| http://purl.uniprot.org/citations/29396289 | http://purl.uniprot.org/core/author | "Okondo M.C."xsd:string |
| http://purl.uniprot.org/citations/29396289 | http://purl.uniprot.org/core/author | "Okondo M.C."xsd:string |
| http://purl.uniprot.org/citations/29396289 | http://purl.uniprot.org/core/author | "Rao S.D."xsd:string |
| http://purl.uniprot.org/citations/29396289 | http://purl.uniprot.org/core/author | "Rao S.D."xsd:string |
| http://purl.uniprot.org/citations/29396289 | http://purl.uniprot.org/core/author | "Taabazuing C.Y."xsd:string |
| http://purl.uniprot.org/citations/29396289 | http://purl.uniprot.org/core/author | "Taabazuing C.Y."xsd:string |
| http://purl.uniprot.org/citations/29396289 | http://purl.uniprot.org/core/author | "Poplawski S.E."xsd:string |
| http://purl.uniprot.org/citations/29396289 | http://purl.uniprot.org/core/author | "Poplawski S.E."xsd:string |
| http://purl.uniprot.org/citations/29396289 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29396289 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29396289 | http://purl.uniprot.org/core/name | "Cell Chem. Biol."xsd:string |
| http://purl.uniprot.org/citations/29396289 | http://purl.uniprot.org/core/name | "Cell Chem. Biol."xsd:string |
| http://purl.uniprot.org/citations/29396289 | http://purl.uniprot.org/core/pages | "262-267"xsd:string |
| http://purl.uniprot.org/citations/29396289 | http://purl.uniprot.org/core/pages | "262-267"xsd:string |