| http://purl.uniprot.org/citations/29396424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29396424 | http://www.w3.org/2000/01/rdf-schema#comment | "RPS27L (ribosomal protein S27-like) is an evolutionarily conserved ribosomal protein and a direct p53 target. We recently reported that Rps27l disruption triggers ribosomal stress to induce p53, causing postnatal death, which can be rescued by Trp53 +/- . Whether and how Rps27l modulates radiosensitivity is unknown. Here we report that Rps27l -/- ; Trp53 +/- mice are extremely sensitive to radiation due to reduced proliferation and massive induction of apoptosis in radiation-sensitive organs. Mechanistically, the radiation sensitivity is mediated by two signaling pathways: (1) activated p53 pathway due to imbalanced Mdm2/Mdm4 levels and reduced E3 ligase activity; and (2) reduced DNA damage response due to reduced MRN/Atm signal as a result of elevated Mdm2 binding of Nbs1 to inhibit Nbs1-Atm binding and subsequent Atm activation. Indeed, heterozygous deletion of Mdm2 restores the MRN/Atm signal. Collectively, our study revealed a physiological condition under which Rps27l regulates the Mdm2/p53 and MRN/Atm axes to maintain DNA damage response and to confer radioprotection in vivo."xsd:string |
| http://purl.uniprot.org/citations/29396424 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41419-017-0192-3"xsd:string |
| http://purl.uniprot.org/citations/29396424 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/29396424 | http://purl.uniprot.org/core/author | "Sun Y."xsd:string |
| http://purl.uniprot.org/citations/29396424 | http://purl.uniprot.org/core/author | "Tan M."xsd:string |
| http://purl.uniprot.org/citations/29396424 | http://purl.uniprot.org/core/author | "Xiong X."xsd:string |
| http://purl.uniprot.org/citations/29396424 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/29396424 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29396424 | http://purl.uniprot.org/core/name | "Cell Death Dis"xsd:string |
| http://purl.uniprot.org/citations/29396424 | http://purl.uniprot.org/core/pages | "145"xsd:string |
| http://purl.uniprot.org/citations/29396424 | http://purl.uniprot.org/core/title | "Inactivation of ribosomal protein S27-like confers radiosensitivity via the Mdm2-p53 and Mdm2-MRN-ATM axes."xsd:string |
| http://purl.uniprot.org/citations/29396424 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/29396424 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29396424 |
| http://purl.uniprot.org/citations/29396424 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29396424 |
| http://purl.uniprot.org/uniprot/#_D3YYB0-mappedCitation-29396424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29396424 |
| http://purl.uniprot.org/uniprot/#_A0A158SIS7-mappedCitation-29396424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29396424 |
| http://purl.uniprot.org/uniprot/#_A0A5Q0MU23-mappedCitation-29396424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29396424 |
| http://purl.uniprot.org/uniprot/#_D6RH49-mappedCitation-29396424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29396424 |
| http://purl.uniprot.org/uniprot/#_F6S6Q3-mappedCitation-29396424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29396424 |
| http://purl.uniprot.org/uniprot/#_P02340-mappedCitation-29396424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29396424 |
| http://purl.uniprot.org/uniprot/#_I7HIK9-mappedCitation-29396424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29396424 |
| http://purl.uniprot.org/uniprot/#_Q91XH8-mappedCitation-29396424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29396424 |
| http://purl.uniprot.org/uniprot/#_Q3UGQ1-mappedCitation-29396424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29396424 |
| http://purl.uniprot.org/uniprot/#_O70366-mappedCitation-29396424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29396424 |