| http://purl.uniprot.org/citations/29408684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29408684 | http://www.w3.org/2000/01/rdf-schema#comment | "In this study, an inflammation-targeted delivery system based on a liposomal carrier was developed to deliver hydrophobic dexamethasone against arthritis. Using two FDA-approved excipients for intravenous injection, dexamethasone loaded liposome (Dex-Lip) was prepared by a thin-film hydration method. The biodistribution of 1,1'-dioctadecyl-3,3,3',3'-tetramethylindodicarbocyanine-loaded liposomes (DiD-Lips) were performed in rats with adjuvant-induced arthritis and demonstrated specific targeting efficacy in the disease site. DiD-Lips showed prolonged retention time in the inflammatory joint tissues compared with free DiD. Dex-Lips effectively suppressed the joint swelling in arthritis rats and significantly down-regulated serum pro-inflammatory cytokines including tumor necrosis factor-α and interleukin-1β when compared to free dexamethasone. Furthermore, Dex-Lips had no significantly impact on the body weight, alleviated the hyperglycemia and improved haematological profiles of rheumatoid arthritis rats during the treatment process. Taken together, a safe liposomal delivery system was developed to achieve inflammation targeted therapy against arthritis."xsd:string |
| http://purl.uniprot.org/citations/29408684 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ijpharm.2018.02.001"xsd:string |
| http://purl.uniprot.org/citations/29408684 | http://purl.uniprot.org/core/author | "Luo J."xsd:string |
| http://purl.uniprot.org/citations/29408684 | http://purl.uniprot.org/core/author | "Jia M."xsd:string |
| http://purl.uniprot.org/citations/29408684 | http://purl.uniprot.org/core/author | "Sun X."xsd:string |
| http://purl.uniprot.org/citations/29408684 | http://purl.uniprot.org/core/author | "Zhang P."xsd:string |
| http://purl.uniprot.org/citations/29408684 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/29408684 | http://purl.uniprot.org/core/author | "Deng C."xsd:string |
| http://purl.uniprot.org/citations/29408684 | http://purl.uniprot.org/core/author | "Gong T."xsd:string |
| http://purl.uniprot.org/citations/29408684 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29408684 | http://purl.uniprot.org/core/name | "Int J Pharm"xsd:string |
| http://purl.uniprot.org/citations/29408684 | http://purl.uniprot.org/core/pages | "57-64"xsd:string |
| http://purl.uniprot.org/citations/29408684 | http://purl.uniprot.org/core/title | "A novel dexamethasone-loaded liposome alleviates rheumatoid arthritis in rats."xsd:string |
| http://purl.uniprot.org/citations/29408684 | http://purl.uniprot.org/core/volume | "540"xsd:string |
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