http://purl.uniprot.org/citations/29408956 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/29408956 | http://www.w3.org/2000/01/rdf-schema#comment | "During translation's elongation cycle, elongation factor G (EF-G) promotes messenger and transfer RNA translocation through the ribosome. Until now, the structures reported for EF-G-ribosome complexes have been obtained by trapping EF-G in the ribosome. These results were based on use of non-hydrolyzable guanosine 5'-triphosphate (GTP) analogs, specific inhibitors or a mutated EF-G form. Here, we present the first cryo-electron microscopy structure of EF-G bound to ribosome in the absence of an inhibitor. The structure reveals a natural conformation of EF-G·GDP in the ribosome, with a previously unseen conformation of its third domain. These data show how EF-G must affect translocation, and suggest the molecular mechanism by which fusidic acid antibiotic prevents the release of EF-G after GTP hydrolysis."xsd:string |
http://purl.uniprot.org/citations/29408956 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gky081"xsd:string |
http://purl.uniprot.org/citations/29408956 | http://purl.uniprot.org/core/author | "Gillet R."xsd:string |
http://purl.uniprot.org/citations/29408956 | http://purl.uniprot.org/core/author | "Mace K."xsd:string |
http://purl.uniprot.org/citations/29408956 | http://purl.uniprot.org/core/author | "Giudice E."xsd:string |
http://purl.uniprot.org/citations/29408956 | http://purl.uniprot.org/core/author | "Chat S."xsd:string |
http://purl.uniprot.org/citations/29408956 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
http://purl.uniprot.org/citations/29408956 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
http://purl.uniprot.org/citations/29408956 | http://purl.uniprot.org/core/pages | "3211-3217"xsd:string |
http://purl.uniprot.org/citations/29408956 | http://purl.uniprot.org/core/title | "The structure of an elongation factor G-ribosome complex captured in the absence of inhibitors."xsd:string |
http://purl.uniprot.org/citations/29408956 | http://purl.uniprot.org/core/volume | "46"xsd:string |
http://purl.uniprot.org/citations/29408956 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29408956 |
http://purl.uniprot.org/citations/29408956 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29408956 |
http://purl.uniprot.org/uniprot/#_P35871-mappedCitation-29408956 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29408956 |
http://purl.uniprot.org/uniprot/#_P0DOY6-mappedCitation-29408956 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29408956 |
http://purl.uniprot.org/uniprot/#_P0DOY7-mappedCitation-29408956 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29408956 |
http://purl.uniprot.org/uniprot/#_P0DOY8-mappedCitation-29408956 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29408956 |
http://purl.uniprot.org/uniprot/#_P0DOY9-mappedCitation-29408956 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29408956 |
http://purl.uniprot.org/uniprot/#_P17291-mappedCitation-29408956 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29408956 |
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http://purl.uniprot.org/uniprot/#_P80340-mappedCitation-29408956 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29408956 |
http://purl.uniprot.org/uniprot/#_P80371-mappedCitation-29408956 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29408956 |
http://purl.uniprot.org/uniprot/#_P80372-mappedCitation-29408956 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29408956 |
http://purl.uniprot.org/uniprot/#_P80373-mappedCitation-29408956 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29408956 |