| http://purl.uniprot.org/citations/29409356 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29409356 | http://www.w3.org/2000/01/rdf-schema#comment | "Postprandial glucose-induced insulin secretion from the islets of Langerhans is facilitated by glucagon-like peptide-1 (GLP-1)-a metabolic hormone with insulinotropic properties. Among the variety of effects it mediates, GLP-1 induces delta cell secretion of somatostatin, inhibits alpha cell release of glucagon, reduces gastric emptying, and slows food intake. These events collectively contribute to weight loss over time. During type 2 diabetes (T2DM), however, the incretin response to glucose is reduced and accompanied by a moderate reduction in GLP-1 secretion. To compensate for the reduced incretin effect, a human immunodeficiency virus-based lentiviral vector was generated to deliver DNA encoding human GLP-1 (LentiGLP-1), and the anti-diabetic efficacy of LentiGLP-1 was tested in a high-fat diet/streptozotocin-induced model of T2DM. Therapeutic administration of LentiGLP-1 reduced blood glucose levels in obese diabetic Sprague Dawley rats, along with improving insulin sensitivity and glucose tolerance. Normoglycemia was correlated with increased blood GLP-1 and pancreatic beta cell regeneration in LentiGLP-1-treated rats. Plasma triglyceride levels were also normalized after LentiGLP-1 injection. Collectively, these data suggest the clinical potential of GLP-1 gene transfer therapy for the treatment of T2DM."xsd:string |
| http://purl.uniprot.org/citations/29409356 | http://purl.org/dc/terms/identifier | "doi:10.1089/hum.2017.180"xsd:string |
| http://purl.uniprot.org/citations/29409356 | http://purl.uniprot.org/core/author | "Griffith T.S."xsd:string |
| http://purl.uniprot.org/citations/29409356 | http://purl.uniprot.org/core/author | "Sanlioglu S."xsd:string |
| http://purl.uniprot.org/citations/29409356 | http://purl.uniprot.org/core/author | "Balci M.K."xsd:string |
| http://purl.uniprot.org/citations/29409356 | http://purl.uniprot.org/core/author | "Altunbas H.A."xsd:string |
| http://purl.uniprot.org/citations/29409356 | http://purl.uniprot.org/core/author | "Tasyurek H.M."xsd:string |
| http://purl.uniprot.org/citations/29409356 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29409356 | http://purl.uniprot.org/core/name | "Hum Gene Ther"xsd:string |
| http://purl.uniprot.org/citations/29409356 | http://purl.uniprot.org/core/pages | "802-815"xsd:string |
| http://purl.uniprot.org/citations/29409356 | http://purl.uniprot.org/core/title | "Therapeutic Potential of Lentivirus-Mediated Glucagon-Like Peptide-1 Gene Therapy for Diabetes."xsd:string |
| http://purl.uniprot.org/citations/29409356 | http://purl.uniprot.org/core/volume | "29"xsd:string |
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