| http://purl.uniprot.org/citations/29415899 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29415899 | http://www.w3.org/2000/01/rdf-schema#comment | "Exercise induces the expression of peroxisome proliferator-activated receptor gamma co-activator 1-α (PGC-1α) in skeletal muscle, which promotes the cleavage of fibronectin type III domain-containing protein 5 (FNDC5) to irisin. To explore the relationship between irisin and its regulators, we analyzed the plasma irisin levels and the muscle levels of FNDC5 and PGC-1α after exercise. Male C57BL/6J mice underwent a treadmill exercise (60% of VO2max) for 30 min or one hour (h), and blood and gastrocnemius samples were collected before exercise (pre-exercise), immediately after exercise, and during 24-h recovery after 1-h exercise. We found that plasma irisin levels were significantly increased during exercise (P < 0.05), while FNDC5 protein levels were not significantly increased. Moreover, PGC-1α mRNA and protein levels were significantly increased during 30-min exercise, but were decreased during 1-h exercise. After 1-h exercise, the irisin levels peaked at 6 h (20.71 ± 0.25 ng/ml) and decreased to pre-exercise levels by 24 h (15.45 ± 0.27 ng/ml). Likewise, PGC-1α mRNA and protein levels were increased at 1 h and maintained at elevated levels for 6 h; thereafter, the expression levels of PGC1-α protein were decreased to pre-exercise levels at 12 h. Thus, the restoration of PGC-1α expression to the pre-exercise levels was followed by the decrease in plasma irisin levels. By contrast, during 24-h recovery, the expression levels of FNDC5 mRNA and protein were maintained at elevated levels. These results suggest that the coordinated expression of FNDC5 and PGC-1α may contribute to the increased levels of plasma irisin after exercise."xsd:string |
| http://purl.uniprot.org/citations/29415899 | http://purl.org/dc/terms/identifier | "doi:10.1620/tjem.244.93"xsd:string |
| http://purl.uniprot.org/citations/29415899 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/29415899 | http://purl.uniprot.org/core/author | "Dong X."xsd:string |
| http://purl.uniprot.org/citations/29415899 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/29415899 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/29415899 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/29415899 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/29415899 | http://purl.uniprot.org/core/author | "Pang M."xsd:string |
| http://purl.uniprot.org/citations/29415899 | http://purl.uniprot.org/core/author | "Rao J."xsd:string |
| http://purl.uniprot.org/citations/29415899 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29415899 | http://purl.uniprot.org/core/name | "Tohoku J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/29415899 | http://purl.uniprot.org/core/pages | "93-103"xsd:string |
| http://purl.uniprot.org/citations/29415899 | http://purl.uniprot.org/core/title | "Time-Dependent Changes in Increased Levels of Plasma Irisin and Muscle PGC-1alpha and FNDC5 after Exercise in Mice."xsd:string |
| http://purl.uniprot.org/citations/29415899 | http://purl.uniprot.org/core/volume | "244"xsd:string |
| http://purl.uniprot.org/citations/29415899 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29415899 |
| http://purl.uniprot.org/citations/29415899 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29415899 |
| http://purl.uniprot.org/uniprot/#_Q3LIF9-mappedCitation-29415899 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29415899 |
| http://purl.uniprot.org/uniprot/#_Q3LIG0-mappedCitation-29415899 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29415899 |
| http://purl.uniprot.org/uniprot/#_Q3LIG2-mappedCitation-29415899 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29415899 |
| http://purl.uniprot.org/uniprot/#_Q8BRP2-mappedCitation-29415899 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29415899 |
| http://purl.uniprot.org/uniprot/#_O70343-mappedCitation-29415899 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29415899 |
| http://purl.uniprot.org/uniprot/#_Q8K4Z2-mappedCitation-29415899 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29415899 |
| http://purl.uniprot.org/uniprot/#_Q8CCT1-mappedCitation-29415899 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29415899 |