| http://purl.uniprot.org/citations/29420171 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29420171 | http://www.w3.org/2000/01/rdf-schema#comment | "Spatial control of G-protein-coupled receptor (GPCR) signaling, which is used by cells to translate complex information into distinct downstream responses, is achieved by using plasma membrane (PM) and endocytic-derived signaling pathways. The roles of the endomembrane in regulating such pleiotropic signaling via multiple G-protein pathways remain unknown. Here, we investigated the effects of disease-causing mutations of the adaptor protein-2σ subunit (AP2σ) on signaling by the class C GPCR calcium-sensing receptor (CaSR). These AP2σ mutations increase CaSR PM expression yet paradoxically reduce CaSR signaling. Hypercalcemia-associated AP2σ mutations reduced CaSR signaling via Gαq/11 and Gαi/o pathways. The mutations also delayed CaSR internalization due to prolonged residency time of CaSR in clathrin structures that impaired or abolished endosomal signaling, which was predominantly mediated by Gαq/11. Thus, compartmental bias for CaSR-mediated Gαq/11 endomembrane signaling provides a mechanistic basis for multidimensional GPCR signaling."xsd:string |
| http://purl.uniprot.org/citations/29420171 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2017.12.089"xsd:string |
| http://purl.uniprot.org/citations/29420171 | http://purl.uniprot.org/core/author | "Inoue A."xsd:string |
| http://purl.uniprot.org/citations/29420171 | http://purl.uniprot.org/core/author | "Thakker R.V."xsd:string |
| http://purl.uniprot.org/citations/29420171 | http://purl.uniprot.org/core/author | "Whyte M.P."xsd:string |
| http://purl.uniprot.org/citations/29420171 | http://purl.uniprot.org/core/author | "Breitwieser G.E."xsd:string |
| http://purl.uniprot.org/citations/29420171 | http://purl.uniprot.org/core/author | "Rorsman P."xsd:string |
| http://purl.uniprot.org/citations/29420171 | http://purl.uniprot.org/core/author | "Hanyaloglu A.C."xsd:string |
| http://purl.uniprot.org/citations/29420171 | http://purl.uniprot.org/core/author | "Frost M."xsd:string |
| http://purl.uniprot.org/citations/29420171 | http://purl.uniprot.org/core/author | "Tarasov A.I."xsd:string |
| http://purl.uniprot.org/citations/29420171 | http://purl.uniprot.org/core/author | "Gorvin C.M."xsd:string |
| http://purl.uniprot.org/citations/29420171 | http://purl.uniprot.org/core/author | "Hastoy B."xsd:string |
| http://purl.uniprot.org/citations/29420171 | http://purl.uniprot.org/core/author | "Rogers A."xsd:string |
| http://purl.uniprot.org/citations/29420171 | http://purl.uniprot.org/core/author | "Sposini S."xsd:string |
| http://purl.uniprot.org/citations/29420171 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29420171 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/29420171 | http://purl.uniprot.org/core/pages | "1054-1066"xsd:string |
| http://purl.uniprot.org/citations/29420171 | http://purl.uniprot.org/core/title | "AP2sigma Mutations Impair Calcium-Sensing Receptor Trafficking and Signaling, and Show an Endosomal Pathway to Spatially Direct G-Protein Selectivity."xsd:string |
| http://purl.uniprot.org/citations/29420171 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/29420171 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29420171 |
| http://purl.uniprot.org/citations/29420171 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29420171 |
| http://purl.uniprot.org/uniprot/#_P53680-mappedCitation-29420171 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29420171 |
| http://purl.uniprot.org/uniprot/#_M0QYZ2-mappedCitation-29420171 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29420171 |
| http://purl.uniprot.org/uniprot/#_M0R0N4-mappedCitation-29420171 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29420171 |