| http://purl.uniprot.org/citations/29431690 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29431690 | http://www.w3.org/2000/01/rdf-schema#comment | "ILDR2 is a member of the Ig superfamily, which is implicated in tricellular tight junctions, and has a putative role in pancreatic islet health and survival. We recently found a novel role for ILDR2 in delivering inhibitory signals to T cells. In this article, we show that short-term treatment with ILDR2-Fc results in long-term durable beneficial effects in the relapsing-remitting experimental autoimmune encephalomyelitis and NOD type 1 diabetes models. ILDR2-Fc also promotes transplant engraftment in a minor mismatch bone marrow transplantation model. ILDR2-Fc displays a unique mode of action, combining immunomodulation, regulation of immune homeostasis, and re-establishment of Ag-specific immune tolerance via regulatory T cell induction. These findings support the potential of ILDR-Fc to provide a promising therapeutic approach for the treatment of autoimmune diseases."xsd:string |
| http://purl.uniprot.org/citations/29431690 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1700326"xsd:string |
| http://purl.uniprot.org/citations/29431690 | http://purl.uniprot.org/core/author | "Rotman G."xsd:string |
| http://purl.uniprot.org/citations/29431690 | http://purl.uniprot.org/core/author | "Chiang M.Y."xsd:string |
| http://purl.uniprot.org/citations/29431690 | http://purl.uniprot.org/core/author | "Hecht I."xsd:string |
| http://purl.uniprot.org/citations/29431690 | http://purl.uniprot.org/core/author | "Miller S.D."xsd:string |
| http://purl.uniprot.org/citations/29431690 | http://purl.uniprot.org/core/author | "Neria E."xsd:string |
| http://purl.uniprot.org/citations/29431690 | http://purl.uniprot.org/core/author | "Novik A."xsd:string |
| http://purl.uniprot.org/citations/29431690 | http://purl.uniprot.org/core/author | "Podojil J.R."xsd:string |
| http://purl.uniprot.org/citations/29431690 | http://purl.uniprot.org/core/author | "Vaknin I."xsd:string |
| http://purl.uniprot.org/citations/29431690 | http://purl.uniprot.org/core/author | "Barbiro I."xsd:string |
| http://purl.uniprot.org/citations/29431690 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29431690 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/29431690 | http://purl.uniprot.org/core/pages | "2013-2024"xsd:string |
| http://purl.uniprot.org/citations/29431690 | http://purl.uniprot.org/core/title | "ILDR2-Fc Is a Novel Regulator of Immune Homeostasis and Inducer of Antigen-Specific Immune Tolerance."xsd:string |
| http://purl.uniprot.org/citations/29431690 | http://purl.uniprot.org/core/volume | "200"xsd:string |
| http://purl.uniprot.org/citations/29431690 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29431690 |
| http://purl.uniprot.org/citations/29431690 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29431690 |
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| http://purl.uniprot.org/uniprot/#_A0A0A6YXV2-mappedCitation-29431690 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29431690 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YY19-mappedCitation-29431690 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29431690 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YY76-mappedCitation-29431690 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29431690 |