| http://purl.uniprot.org/citations/29431694 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29431694 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29431694 | http://www.w3.org/2000/01/rdf-schema#comment | "The B7-like protein family members play critical immunomodulatory roles and constitute attractive targets for the development of novel therapies for human diseases. We identified Ig-like domain-containing receptor (ILDR)2 as a novel B7-like protein with robust T cell inhibitory activity, expressed in immune cells and in immune-privileged and inflamed tissues. A fusion protein, consisting of ILDR2 extracellular domain with an Fc fragment, that binds to a putative counterpart on activated T cells showed a beneficial effect in the collagen-induced arthritis model and abrogated the production of proinflammatory cytokines and chemokines in autologous synovial-like cocultures of macrophages and cytokine-stimulated T cells. Collectively, these findings point to ILDR2 as a novel negative regulator for T cells, with potential roles in the development of immune-related diseases, including autoimmunity and cancer."xsd:string |
| http://purl.uniprot.org/citations/29431694 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1700325"xsd:string |
| http://purl.uniprot.org/citations/29431694 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1700325"xsd:string |
| http://purl.uniprot.org/citations/29431694 | http://purl.uniprot.org/core/author | "Oren A."xsd:string |
| http://purl.uniprot.org/citations/29431694 | http://purl.uniprot.org/core/author | "Oren A."xsd:string |
| http://purl.uniprot.org/citations/29431694 | http://purl.uniprot.org/core/author | "Williams R.O."xsd:string |
| http://purl.uniprot.org/citations/29431694 | http://purl.uniprot.org/core/author | "Williams R.O."xsd:string |
| http://purl.uniprot.org/citations/29431694 | http://purl.uniprot.org/core/author | "Liang S.C."xsd:string |
| http://purl.uniprot.org/citations/29431694 | http://purl.uniprot.org/core/author | "Liang S.C."xsd:string |
| http://purl.uniprot.org/citations/29431694 | http://purl.uniprot.org/core/author | "Rotman G."xsd:string |
| http://purl.uniprot.org/citations/29431694 | http://purl.uniprot.org/core/author | "Rotman G."xsd:string |
| http://purl.uniprot.org/citations/29431694 | http://purl.uniprot.org/core/author | "Leitner J."xsd:string |
| http://purl.uniprot.org/citations/29431694 | http://purl.uniprot.org/core/author | "Leitner J."xsd:string |
| http://purl.uniprot.org/citations/29431694 | http://purl.uniprot.org/core/author | "Steinberger P."xsd:string |
| http://purl.uniprot.org/citations/29431694 | http://purl.uniprot.org/core/author | "Steinberger P."xsd:string |
| http://purl.uniprot.org/citations/29431694 | http://purl.uniprot.org/core/author | "McIntyre D."xsd:string |
| http://purl.uniprot.org/citations/29431694 | http://purl.uniprot.org/core/author | "McIntyre D."xsd:string |
| http://purl.uniprot.org/citations/29431694 | http://purl.uniprot.org/core/author | "Toporik A."xsd:string |
| http://purl.uniprot.org/citations/29431694 | http://purl.uniprot.org/core/author | "Toporik A."xsd:string |
| http://purl.uniprot.org/citations/29431694 | http://purl.uniprot.org/core/author | "McInnes I.B."xsd:string |
| http://purl.uniprot.org/citations/29431694 | http://purl.uniprot.org/core/author | "McInnes I.B."xsd:string |
| http://purl.uniprot.org/citations/29431694 | http://purl.uniprot.org/core/author | "Kurowska-Stolarska M."xsd:string |
| http://purl.uniprot.org/citations/29431694 | http://purl.uniprot.org/core/author | "Kurowska-Stolarska M."xsd:string |