| http://purl.uniprot.org/citations/29432179 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29432179 | http://www.w3.org/2000/01/rdf-schema#comment | "Maintenance of genome integrity is critical for both faithful propagation of genetic information and prevention of mutagenesis induced by various DNA damage events. Here we report cold-inducible RNA-binding protein (CIRBP) as a newly identified key regulator in DNA double-strand break (DSB) repair. On DNA damage, CIRBP temporarily accumulates at the damaged regions and is poly(ADP ribosyl)ated by poly(ADP ribose) polymerase-1 (PARP-1). Its dissociation from the sites of damage may depend on its phosphorylation status as mediated by phosphatidylinositol 3-kinase-related kinases. In the absence of CIRBP, cells showed reduced γH2AX, Rad51, and 53BP1 foci formation. Moreover, CIRBP-depleted cells exhibited impaired homologous recombination, impaired nonhomologous end-joining, increased micronuclei formation, and higher sensitivity to gamma irradiation, demonstrating the active involvement of CIRBP in DSB repair. Furthermore, CIRBP depleted cells exhibited defects in DNA damage-induced chromatin association of the MRN complex (Mre11, Rad50, and NBS1) and ATM kinase. CIRBP depletion also reduced phosphorylation of a variety of ATM substrate proteins and thus impaired the DNA damage response. Taken together, these results reveal a previously unrecognized role for CIRBP in DSB repair."xsd:string |
| http://purl.uniprot.org/citations/29432179 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1713912115"xsd:string |
| http://purl.uniprot.org/citations/29432179 | http://purl.uniprot.org/core/author | "Chen Z."xsd:string |
| http://purl.uniprot.org/citations/29432179 | http://purl.uniprot.org/core/author | "Lin W.L."xsd:string |
| http://purl.uniprot.org/citations/29432179 | http://purl.uniprot.org/core/author | "Liu H.W."xsd:string |
| http://purl.uniprot.org/citations/29432179 | http://purl.uniprot.org/core/author | "Chen J.K."xsd:string |
| http://purl.uniprot.org/citations/29432179 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29432179 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/29432179 | http://purl.uniprot.org/core/pages | "E1759-E1768"xsd:string |
| http://purl.uniprot.org/citations/29432179 | http://purl.uniprot.org/core/title | "PARP-1-dependent recruitment of cold-inducible RNA-binding protein promotes double-strand break repair and genome stability."xsd:string |
| http://purl.uniprot.org/citations/29432179 | http://purl.uniprot.org/core/volume | "115"xsd:string |
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