| http://purl.uniprot.org/citations/29437779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29437779 | http://www.w3.org/2000/01/rdf-schema#comment | "Many metazoan developmental processes require cells to transition between migratory mesenchymal- and adherent epithelial-like states. These transitions require Rho GTPase-mediated actin rearrangements downstream of integrin and cadherin pathways. A regulatory toolbox of GEF and GAP proteins precisely coordinates Rho protein activities, yet defining the involvement of specific regulators within a cellular context remains a challenge due to overlapping and coupled activities. Here we demonstrate that Drosophila dorsal closure is a powerful model for Rho GTPase regulation during transitions from leading edges to cadherin contacts. During these transitions a Rac GEF elmo-mbc complex regulates both lamellipodia and Rho1-dependent, actomyosin-mediated tension at initial cadherin contacts. Moreover, the Rho GAP Rhogap19d controls Rac and Rho GTPases during the same processes and genetically regulates the elmo-mbc complex. This study presents a fresh framework to understand the inter-relationship between GEF and GAP proteins that tether Rac and Rho cycles during developmental processes."xsd:string |
| http://purl.uniprot.org/citations/29437779 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.157495"xsd:string |
| http://purl.uniprot.org/citations/29437779 | http://purl.uniprot.org/core/author | "Toret C.P."xsd:string |
| http://purl.uniprot.org/citations/29437779 | http://purl.uniprot.org/core/author | "Le Bivic A."xsd:string |
| http://purl.uniprot.org/citations/29437779 | http://purl.uniprot.org/core/author | "Lenne P.F."xsd:string |
| http://purl.uniprot.org/citations/29437779 | http://purl.uniprot.org/core/author | "Shivakumar P.C."xsd:string |
| http://purl.uniprot.org/citations/29437779 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29437779 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/29437779 | http://purl.uniprot.org/core/pages | "dev.157495"xsd:string |
| http://purl.uniprot.org/citations/29437779 | http://purl.uniprot.org/core/title | "The elmo-mbc complex and rhogap19d couple Rho family GTPases during mesenchymal-to-epithelial-like transitions."xsd:string |
| http://purl.uniprot.org/citations/29437779 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29437779 |
| http://purl.uniprot.org/citations/29437779 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29437779 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KGS4-mappedCitation-29437779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29437779 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K7Q6-mappedCitation-29437779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29437779 |
| http://purl.uniprot.org/uniprot/#_F6J1D0-mappedCitation-29437779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29437779 |
| http://purl.uniprot.org/uniprot/#_B7Z0W0-mappedCitation-29437779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29437779 |
| http://purl.uniprot.org/uniprot/#_E1JJS2-mappedCitation-29437779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29437779 |
| http://purl.uniprot.org/uniprot/#_M9NFH4-mappedCitation-29437779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29437779 |
| http://purl.uniprot.org/uniprot/#_M9PBH7-mappedCitation-29437779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29437779 |
| http://purl.uniprot.org/uniprot/#_P40792-mappedCitation-29437779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29437779 |
| http://purl.uniprot.org/uniprot/#_P40423-mappedCitation-29437779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29437779 |
| http://purl.uniprot.org/uniprot/#_Q24298-mappedCitation-29437779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29437779 |
| http://purl.uniprot.org/uniprot/#_P48148-mappedCitation-29437779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29437779 |
| http://purl.uniprot.org/uniprot/#_Q8IGZ0-mappedCitation-29437779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29437779 |