| http://purl.uniprot.org/citations/29438108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29438108 | http://www.w3.org/2000/01/rdf-schema#comment | "Immune evasion and the suppression of antitumor responses during cancer progression are considered hallmarks of cancer and are typically attributed to tumor-derived factors. Although the molecular basis for the crosstalk between tumor and immune cells is an area of active investigation, whether host-specific germline variants can dictate immunosuppressive mechanisms has remained a challenge to address. A commonly occurring germline mutation (c.1162G>A/rs351855 G/A) in the FGFR4 (CD334) gene enhances signal transducer and activator of transcription 3 (STAT3) signaling and is associated with poor prognosis and accelerated progression of multiple cancer types. Here, using rs351855 SNP-knockin transgenic mice and Fgfr4-knockout mice, we reveal the genotype-specific gain of immunological function of suppressing the CD8/CD4+FOXP3+CD25+ regulatory T cell ratio in vivo. Furthermore, using knockin transgenic mouse models for lung and breast cancers, we establish the host-specific, tumor-extrinsic functions of STAT3-enhancing germline variants in impeding the tumor infiltration of CD8 T cells. Thus, STAT3-enhancing germline receptor variants contribute to immune evasion through their pleiotropic functions in immune cells."xsd:string |
| http://purl.uniprot.org/citations/29438108 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci96708"xsd:string |
| http://purl.uniprot.org/citations/29438108 | http://purl.uniprot.org/core/author | "Faul C."xsd:string |
| http://purl.uniprot.org/citations/29438108 | http://purl.uniprot.org/core/author | "Ulaganathan V.K."xsd:string |
| http://purl.uniprot.org/citations/29438108 | http://purl.uniprot.org/core/author | "Grabner A."xsd:string |
| http://purl.uniprot.org/citations/29438108 | http://purl.uniprot.org/core/author | "Yanucil C."xsd:string |
| http://purl.uniprot.org/citations/29438108 | http://purl.uniprot.org/core/author | "Kogan D."xsd:string |
| http://purl.uniprot.org/citations/29438108 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29438108 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/29438108 | http://purl.uniprot.org/core/pages | "1867-1872"xsd:string |
| http://purl.uniprot.org/citations/29438108 | http://purl.uniprot.org/core/title | "STAT3-enhancing germline mutations contribute to tumor-extrinsic immune evasion."xsd:string |
| http://purl.uniprot.org/citations/29438108 | http://purl.uniprot.org/core/volume | "128"xsd:string |
| http://purl.uniprot.org/citations/29438108 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29438108 |
| http://purl.uniprot.org/citations/29438108 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29438108 |
| http://purl.uniprot.org/uniprot/#_A0A0R4IZY3-mappedCitation-29438108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29438108 |
| http://purl.uniprot.org/uniprot/#_B7ZC18-mappedCitation-29438108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29438108 |
| http://purl.uniprot.org/uniprot/#_Q3ULI4-mappedCitation-29438108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29438108 |
| http://purl.uniprot.org/uniprot/#_Q03142-mappedCitation-29438108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29438108 |
| http://purl.uniprot.org/uniprot/#_Q3U6S9-mappedCitation-29438108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29438108 |
| http://purl.uniprot.org/uniprot/#_P22455-mappedCitation-29438108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29438108 |
| http://purl.uniprot.org/uniprot/#_P42227-mappedCitation-29438108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29438108 |
| http://purl.uniprot.org/uniprot/#_Q6GU23-mappedCitation-29438108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29438108 |
| http://purl.uniprot.org/uniprot/#_Q9ESV4-mappedCitation-29438108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29438108 |
| http://purl.uniprot.org/uniprot/#_Q9ESV5-mappedCitation-29438108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29438108 |