| http://purl.uniprot.org/citations/29438598 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29438598 | http://www.w3.org/2000/01/rdf-schema#comment | "TMEM16A is essential for Ca2+ -activated Cl- conductance in vascular smooth muscle. The importance of TMEM16A for agonist-induced vascular constriction and blood pressure control is, however, under debate. Previous studies suggested that TMEM16A might have a complex cellular function beyond being essential for the Ca2+ -activated Cl- conductance, for example modulation of Ca2+ channel expression. Mice with constitutive, smooth muscle-specific expression of siRNA directed against Tmem16a (transgenic mice, TG) were generated. Isometric constrictions of isolated aorta, mesenteric, femoral and tail arteries from TG mice were compared with wild-types. Protein expression was analysed by Western blots. Blood pressure and heart rate were studied telemetrically. Significant TMEM16A down-regulation was seen in aorta and tail arteries, while no changes were detected in mesenteric and femoral arteries. Contractile responses of mesenteric and femoral arteries from TG and wild-type mice were not different. Aorta from TG mice showed reduced agonist-induced constriction, while their responses to elevated K+ were unchanged. Tail arteries from TG mice also constricted less to adrenergic stimulation than wild-types. Surprisingly, tail arteries from TG mice constricted less to elevated K+ too and were more sensitive to nifedipine-induced relaxation. Consistently, TMEM16A down-regulation in tail arteries was associated with reduction in CACNA1C protein (i.e. vascular L-type Ca2+ channel) expression. No differences in blood pressure and heart rate between the groups were seen. This study suggests a complex contribution of TMEM16A in vascular function. We suggest that TMEM16A modulates arterial contractility, at least in part, indirectly via regulation of CACNA1C expression."xsd:string |
| http://purl.uniprot.org/citations/29438598 | http://purl.org/dc/terms/identifier | "doi:10.1111/bcpt.12984"xsd:string |
| http://purl.uniprot.org/citations/29438598 | http://purl.uniprot.org/core/author | "Jensen A.B."xsd:string |
| http://purl.uniprot.org/citations/29438598 | http://purl.uniprot.org/core/author | "Aalkjaer C."xsd:string |
| http://purl.uniprot.org/citations/29438598 | http://purl.uniprot.org/core/author | "Dam V.S."xsd:string |
| http://purl.uniprot.org/citations/29438598 | http://purl.uniprot.org/core/author | "Matchkov V.V."xsd:string |
| http://purl.uniprot.org/citations/29438598 | http://purl.uniprot.org/core/author | "Fuchtbauer E.M."xsd:string |
| http://purl.uniprot.org/citations/29438598 | http://purl.uniprot.org/core/author | "Boedtkjer D."xsd:string |
| http://purl.uniprot.org/citations/29438598 | http://purl.uniprot.org/core/author | "Joergensen H.B."xsd:string |
| http://purl.uniprot.org/citations/29438598 | http://purl.uniprot.org/core/author | "Kamaev D."xsd:string |
| http://purl.uniprot.org/citations/29438598 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29438598 | http://purl.uniprot.org/core/name | "Basic Clin Pharmacol Toxicol"xsd:string |
| http://purl.uniprot.org/citations/29438598 | http://purl.uniprot.org/core/pages | "30-41"xsd:string |
| http://purl.uniprot.org/citations/29438598 | http://purl.uniprot.org/core/title | "Variable Contribution of TMEM16A to Tone in Murine Arterial Vasculature."xsd:string |
| http://purl.uniprot.org/citations/29438598 | http://purl.uniprot.org/core/volume | "123"xsd:string |
| http://purl.uniprot.org/citations/29438598 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29438598 |
| http://purl.uniprot.org/citations/29438598 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29438598 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MQF2-mappedCitation-29438598 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29438598 |
| http://purl.uniprot.org/uniprot/#_D3YYA4-mappedCitation-29438598 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29438598 |
| http://purl.uniprot.org/uniprot/#_A0A5F8MPM2-mappedCitation-29438598 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29438598 |
| http://purl.uniprot.org/uniprot/#_A0A348BSL7-mappedCitation-29438598 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29438598 |
| http://purl.uniprot.org/uniprot/#_D3Z035-mappedCitation-29438598 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29438598 |
| http://purl.uniprot.org/uniprot/#_G8JL82-mappedCitation-29438598 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29438598 |
| http://purl.uniprot.org/uniprot/#_F6R6E1-mappedCitation-29438598 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29438598 |