| http://purl.uniprot.org/citations/29438698 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29438698 | http://www.w3.org/2000/01/rdf-schema#comment | "Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive Schwann cell (SC)-lineage-derived sarcomas. Molecular events driving SC-to-MPNST transformation are incompletely understood. Here, we show that human MPNSTs exhibit elevated HIPPO-TAZ/YAP expression, and that TAZ/YAP hyperactivity in SCs caused by Lats1/2 loss potently induces high-grade nerve-associated tumors with full penetrance. Lats1/2 deficiency reprograms SCs to a cancerous, progenitor-like phenotype and promotes hyperproliferation. Conversely, disruption of TAZ/YAP activity alleviates tumor burden in Lats1/2-deficient mice and inhibits human MPNST cell proliferation. Moreover, genome-wide profiling reveals that TAZ/YAP-TEAD1 directly activates oncogenic programs, including platelet-derived growth factor receptor (PDGFR) signaling. Co-targeting TAZ/YAP and PDGFR pathways inhibits tumor growth. Thus, our findings establish a previously unrecognized convergence between Lats1/2-TAZ/YAP signaling and MPNST pathogenesis, revealing potential therapeutic targets in these untreatable tumors."xsd:string |
| http://purl.uniprot.org/citations/29438698 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccell.2018.01.005"xsd:string |
| http://purl.uniprot.org/citations/29438698 | http://purl.uniprot.org/core/author | "Deng Y."xsd:string |
| http://purl.uniprot.org/citations/29438698 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/29438698 | http://purl.uniprot.org/core/author | "Xu L."xsd:string |
| http://purl.uniprot.org/citations/29438698 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/29438698 | http://purl.uniprot.org/core/author | "Zheng Y."xsd:string |
| http://purl.uniprot.org/citations/29438698 | http://purl.uniprot.org/core/author | "Wang J.'"xsd:string |
| http://purl.uniprot.org/citations/29438698 | http://purl.uniprot.org/core/author | "Zhao C."xsd:string |
| http://purl.uniprot.org/citations/29438698 | http://purl.uniprot.org/core/author | "Zhou W."xsd:string |
| http://purl.uniprot.org/citations/29438698 | http://purl.uniprot.org/core/author | "Johnson R.L."xsd:string |
| http://purl.uniprot.org/citations/29438698 | http://purl.uniprot.org/core/author | "Choi K."xsd:string |
| http://purl.uniprot.org/citations/29438698 | http://purl.uniprot.org/core/author | "Rao R."xsd:string |
| http://purl.uniprot.org/citations/29438698 | http://purl.uniprot.org/core/author | "Xin M."xsd:string |
| http://purl.uniprot.org/citations/29438698 | http://purl.uniprot.org/core/author | "Remke M."xsd:string |
| http://purl.uniprot.org/citations/29438698 | http://purl.uniprot.org/core/author | "Carroll T.J."xsd:string |
| http://purl.uniprot.org/citations/29438698 | http://purl.uniprot.org/core/author | "Lu Q.R."xsd:string |
| http://purl.uniprot.org/citations/29438698 | http://purl.uniprot.org/core/author | "Rizvi T.A."xsd:string |
| http://purl.uniprot.org/citations/29438698 | http://purl.uniprot.org/core/author | "Ratner N."xsd:string |
| http://purl.uniprot.org/citations/29438698 | http://purl.uniprot.org/core/author | "Stemmer-Rachamimov A.O."xsd:string |
| http://purl.uniprot.org/citations/29438698 | http://purl.uniprot.org/core/author | "Rubin J.B."xsd:string |
| http://purl.uniprot.org/citations/29438698 | http://purl.uniprot.org/core/author | "Wu L.M.N."xsd:string |
| http://purl.uniprot.org/citations/29438698 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29438698 | http://purl.uniprot.org/core/name | "Cancer Cell"xsd:string |