| http://purl.uniprot.org/citations/29439199 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29439199 | http://www.w3.org/2000/01/rdf-schema#comment | "The presynaptic active zone provides sites for vesicle docking and release at central nervous synapses and is essential for speed and accuracy of synaptic transmission. Liprin-α binds to several active zone proteins, and loss-of-function studies in invertebrates established important roles for Liprin-α in neurodevelopment and active zone assembly. However, Liprin-α localization and functions in vertebrates have remained unclear. We used stimulated emission depletion superresolution microscopy to systematically determine the localization of Liprin-α2 and Liprin-α3, the two predominant Liprin-α proteins in the vertebrate brain, relative to other active-zone proteins. Both proteins were widely distributed in hippocampal nerve terminals, and Liprin-α3, but not Liprin-α2, had a prominent component that colocalized with the active-zone proteins Bassoon, RIM, Munc13, RIM-BP, and ELKS. To assess Liprin-α3 functions, we generated Liprin-α3-KO mice by using CRISPR/Cas9 gene editing. We found reduced synaptic vesicle tethering and docking in hippocampal neurons of Liprin-α3-KO mice, and synaptic vesicle exocytosis was impaired. Liprin-α3 KO also led to mild alterations in active zone structure, accompanied by translocation of Liprin-α2 to active zones. These findings establish important roles for Liprin-α3 in active-zone assembly and function, and suggest that interplay between various Liprin-α proteins controls their active-zone localization."xsd:string |
| http://purl.uniprot.org/citations/29439199 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1719012115"xsd:string |
| http://purl.uniprot.org/citations/29439199 | http://purl.uniprot.org/core/author | "Liu C."xsd:string |
| http://purl.uniprot.org/citations/29439199 | http://purl.uniprot.org/core/author | "Fowler S.C."xsd:string |
| http://purl.uniprot.org/citations/29439199 | http://purl.uniprot.org/core/author | "Wong M.Y."xsd:string |
| http://purl.uniprot.org/citations/29439199 | http://purl.uniprot.org/core/author | "Kaeser P.S."xsd:string |
| http://purl.uniprot.org/citations/29439199 | http://purl.uniprot.org/core/author | "Wang S.S.H."xsd:string |
| http://purl.uniprot.org/citations/29439199 | http://purl.uniprot.org/core/author | "Roquas A.C.F."xsd:string |
| http://purl.uniprot.org/citations/29439199 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29439199 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/29439199 | http://purl.uniprot.org/core/pages | "2234-2239"xsd:string |
| http://purl.uniprot.org/citations/29439199 | http://purl.uniprot.org/core/title | "Liprin-alpha3 controls vesicle docking and exocytosis at the active zone of hippocampal synapses."xsd:string |
| http://purl.uniprot.org/citations/29439199 | http://purl.uniprot.org/core/volume | "115"xsd:string |
| http://purl.uniprot.org/citations/29439199 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29439199 |
| http://purl.uniprot.org/citations/29439199 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29439199 |
| http://purl.uniprot.org/uniprot/Q6PH08#attribution-FF58FE4F548D79A01876F674E0B50C11 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/29439199 |
| http://purl.uniprot.org/uniprot/Q8BSS9#attribution-FF58FE4F548D79A01876F674E0B50C11 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/29439199 |
| http://purl.uniprot.org/uniprot/P60469#attribution-FF58FE4F548D79A01876F674E0B50C11 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/29439199 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GRM4-mappedCitation-29439199 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29439199 |
| http://purl.uniprot.org/uniprot/#_C7G3P1-mappedCitation-29439199 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29439199 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GS69-mappedCitation-29439199 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29439199 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GSQ8-mappedCitation-29439199 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29439199 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GSU7-mappedCitation-29439199 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29439199 |
| http://purl.uniprot.org/uniprot/#_B8QI34-mappedCitation-29439199 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29439199 |