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http://purl.uniprot.org/citations/29443965http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/29443965http://www.w3.org/2000/01/rdf-schema#comment"Cerebrovascular disease is the third most common cause of death in developed countries, but our understanding of the cells that compose the cerebral vasculature is limited. Here, using vascular single-cell transcriptomics, we provide molecular definitions for the principal types of blood vascular and vessel-associated cells in the adult mouse brain. We uncover the transcriptional basis of the gradual phenotypic change (zonation) along the arteriovenous axis and reveal unexpected cell type differences: a seamless continuum for endothelial cells versus a punctuated continuum for mural cells. We also provide insight into pericyte organotypicity and define a population of perivascular fibroblast-like cells that are present on all vessel types except capillaries. Our work illustrates the power of single-cell transcriptomics to decode the higher organizational principles of a tissue and may provide the initial chapter in a molecular encyclopaedia of the mammalian vasculature."xsd:string
http://purl.uniprot.org/citations/29443965http://purl.org/dc/terms/identifier"doi:10.1038/nature25739"xsd:string
http://purl.uniprot.org/citations/29443965http://purl.uniprot.org/core/author"Sun Y."xsd:string
http://purl.uniprot.org/citations/29443965http://purl.uniprot.org/core/author"Ando K."xsd:string
http://purl.uniprot.org/citations/29443965http://purl.uniprot.org/core/author"He L."xsd:string
http://purl.uniprot.org/citations/29443965http://purl.uniprot.org/core/author"Betsholtz C."xsd:string
http://purl.uniprot.org/citations/29443965http://purl.uniprot.org/core/author"Andrae J."xsd:string
http://purl.uniprot.org/citations/29443965http://purl.uniprot.org/core/author"Mochizuki N."xsd:string
http://purl.uniprot.org/citations/29443965http://purl.uniprot.org/core/author"Raschperger E."xsd:string
http://purl.uniprot.org/citations/29443965http://purl.uniprot.org/core/author"Keller A."xsd:string
http://purl.uniprot.org/citations/29443965http://purl.uniprot.org/core/author"Lendahl U."xsd:string
http://purl.uniprot.org/citations/29443965http://purl.uniprot.org/core/author"Nahar K."xsd:string
http://purl.uniprot.org/citations/29443965http://purl.uniprot.org/core/author"Lebouvier T."xsd:string
http://purl.uniprot.org/citations/29443965http://purl.uniprot.org/core/author"Mae M.A."xsd:string
http://purl.uniprot.org/citations/29443965http://purl.uniprot.org/core/author"Vanlandewijck M."xsd:string
http://purl.uniprot.org/citations/29443965http://purl.uniprot.org/core/author"Gouveia L."xsd:string
http://purl.uniprot.org/citations/29443965http://purl.uniprot.org/core/author"Lavina B."xsd:string
http://purl.uniprot.org/citations/29443965http://purl.uniprot.org/core/author"Rasanen M."xsd:string
http://purl.uniprot.org/citations/29443965http://purl.uniprot.org/core/author"Del Gaudio F."xsd:string
http://purl.uniprot.org/citations/29443965http://purl.uniprot.org/core/author"Zarb Y."xsd:string
http://purl.uniprot.org/citations/29443965http://purl.uniprot.org/core/date"2018"xsd:gYear
http://purl.uniprot.org/citations/29443965http://purl.uniprot.org/core/name"Nature"xsd:string
http://purl.uniprot.org/citations/29443965http://purl.uniprot.org/core/pages"475-480"xsd:string
http://purl.uniprot.org/citations/29443965http://purl.uniprot.org/core/title"A molecular atlas of cell types and zonation in the brain vasculature."xsd:string