| http://purl.uniprot.org/citations/29444090 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29444090 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29444090 | http://www.w3.org/2000/01/rdf-schema#comment | "Chronic pain is a debilitating problem, and insights in the neurobiology of chronic pain are needed for the development of novel pain therapies. A genome-wide association study implicated the 5p15.2 region in chronic widespread pain. This region includes the coding region for FAM173B, a functionally uncharacterized protein. We demonstrate here that FAM173B is a mitochondrial lysine methyltransferase that promotes chronic pain. Knockdown and sensory neuron overexpression strategies showed that FAM173B is involved in persistent inflammatory and neuropathic pain via a pathway dependent on its methyltransferase activity. FAM173B methyltransferase activity in sensory neurons hyperpolarized mitochondria and promoted macrophage/microglia activation through a reactive oxygen species-dependent pathway. In summary, we uncover a role for methyltransferase activity of FAM173B in the neurobiology of pain. These results also highlight FAM173B methyltransferase activity as a potential therapeutic target to treat debilitating chronic pain conditions."xsd:string |
| http://purl.uniprot.org/citations/29444090 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pbio.2003452"xsd:string |
| http://purl.uniprot.org/citations/29444090 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pbio.2003452"xsd:string |
| http://purl.uniprot.org/citations/29444090 | http://purl.uniprot.org/core/author | "Zhou W."xsd:string |
| http://purl.uniprot.org/citations/29444090 | http://purl.uniprot.org/core/author | "Zhou W."xsd:string |
| http://purl.uniprot.org/citations/29444090 | http://purl.uniprot.org/core/author | "Falnes P.O."xsd:string |
| http://purl.uniprot.org/citations/29444090 | http://purl.uniprot.org/core/author | "Falnes P.O."xsd:string |
| http://purl.uniprot.org/citations/29444090 | http://purl.uniprot.org/core/author | "Malecki J."xsd:string |
| http://purl.uniprot.org/citations/29444090 | http://purl.uniprot.org/core/author | "Malecki J."xsd:string |
| http://purl.uniprot.org/citations/29444090 | http://purl.uniprot.org/core/author | "Eijkelkamp N."xsd:string |
| http://purl.uniprot.org/citations/29444090 | http://purl.uniprot.org/core/author | "Eijkelkamp N."xsd:string |
| http://purl.uniprot.org/citations/29444090 | http://purl.uniprot.org/core/author | "Gonzalez Cano R."xsd:string |
| http://purl.uniprot.org/citations/29444090 | http://purl.uniprot.org/core/author | "Gonzalez Cano R."xsd:string |
| http://purl.uniprot.org/citations/29444090 | http://purl.uniprot.org/core/author | "Habib A.M."xsd:string |
| http://purl.uniprot.org/citations/29444090 | http://purl.uniprot.org/core/author | "Habib A.M."xsd:string |
| http://purl.uniprot.org/citations/29444090 | http://purl.uniprot.org/core/author | "Heijnen C.J."xsd:string |
| http://purl.uniprot.org/citations/29444090 | http://purl.uniprot.org/core/author | "Heijnen C.J."xsd:string |
| http://purl.uniprot.org/citations/29444090 | http://purl.uniprot.org/core/author | "Jakobsson M.E."xsd:string |
| http://purl.uniprot.org/citations/29444090 | http://purl.uniprot.org/core/author | "Jakobsson M.E."xsd:string |
| http://purl.uniprot.org/citations/29444090 | http://purl.uniprot.org/core/author | "Kavelaars A."xsd:string |
| http://purl.uniprot.org/citations/29444090 | http://purl.uniprot.org/core/author | "Kavelaars A."xsd:string |
| http://purl.uniprot.org/citations/29444090 | http://purl.uniprot.org/core/author | "Maas M."xsd:string |
| http://purl.uniprot.org/citations/29444090 | http://purl.uniprot.org/core/author | "Maas M."xsd:string |