| http://purl.uniprot.org/citations/29449556 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29449556 | http://www.w3.org/2000/01/rdf-schema#comment | "Regulatory B cells (Breg) express high levels of CD1d that presents lipid antigens to invariant natural killer T (iNKT) cells. The function of CD1d in Breg biology and iNKT cell activity during inflammation remains unclear. Here we show, using chimeric mice, cell depletion and adoptive cell transfer, that CD1d-lipid presentation by Bregs induces iNKT cells to secrete interferon (IFN)-γ to contribute, partially, to the downregulation of T helper (Th)1 and Th17-adaptive immune responses and ameliorate experimental arthritis. Mice lacking CD1d-expressing B cells develop exacerbated disease compared to wild-type mice, and fail to respond to treatment with the prototypical iNKT cell agonist α-galactosylceramide. The absence of lipid presentation by B cells alters iNKT cell activation with disruption of metabolism regulation and cytokine responses. Thus, we identify a mechanism by which Bregs restrain excessive inflammation via lipid presentation."xsd:string |
| http://purl.uniprot.org/citations/29449556 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-018-02911-y"xsd:string |
| http://purl.uniprot.org/citations/29449556 | http://purl.uniprot.org/core/author | "Drozdov I."xsd:string |
| http://purl.uniprot.org/citations/29449556 | http://purl.uniprot.org/core/author | "Oleinika K."xsd:string |
| http://purl.uniprot.org/citations/29449556 | http://purl.uniprot.org/core/author | "Bosma A."xsd:string |
| http://purl.uniprot.org/citations/29449556 | http://purl.uniprot.org/core/author | "Mauri C."xsd:string |
| http://purl.uniprot.org/citations/29449556 | http://purl.uniprot.org/core/author | "Nistala K."xsd:string |
| http://purl.uniprot.org/citations/29449556 | http://purl.uniprot.org/core/author | "Rosser E.C."xsd:string |
| http://purl.uniprot.org/citations/29449556 | http://purl.uniprot.org/core/author | "Matei D.E."xsd:string |
| http://purl.uniprot.org/citations/29449556 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29449556 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/29449556 | http://purl.uniprot.org/core/pages | "684"xsd:string |
| http://purl.uniprot.org/citations/29449556 | http://purl.uniprot.org/core/title | "CD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells."xsd:string |
| http://purl.uniprot.org/citations/29449556 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/29449556 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29449556 |
| http://purl.uniprot.org/citations/29449556 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29449556 |
| http://purl.uniprot.org/uniprot/#_A0A075B5P6-mappedCitation-29449556 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29449556 |
| http://purl.uniprot.org/uniprot/#_A0A075B6A0-mappedCitation-29449556 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29449556 |
| http://purl.uniprot.org/uniprot/#_A0A7R8GUQ3-mappedCitation-29449556 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29449556 |
| http://purl.uniprot.org/uniprot/#_H3BKE8-mappedCitation-29449556 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29449556 |
| http://purl.uniprot.org/uniprot/#_H3BKN6-mappedCitation-29449556 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29449556 |
| http://purl.uniprot.org/uniprot/#_Q3U879-mappedCitation-29449556 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29449556 |
| http://purl.uniprot.org/uniprot/#_Q3UDL4-mappedCitation-29449556 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29449556 |
| http://purl.uniprot.org/uniprot/#_Q3UDV8-mappedCitation-29449556 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29449556 |