| http://purl.uniprot.org/citations/29449577 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29449577 | http://www.w3.org/2000/01/rdf-schema#comment | "Obesity is a global epidemic affecting chronic inflammatory diseases. Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease that can occur as an extraintestinal manifestation of inflammatory bowel disease (IBD). Previously we reported that patients with PSC who are obese have a higher risk of advanced liver disease. Currently it is unknown how obesity accelerates or worsens PSC. We evaluated the progression of PSC in an antigen-driven cholangitis mouse model of diet-induced obesity. Obesity was induced in our murine model of immune-mediated cholangitis (OVAbil). OVAbil mice were fed standard chow or high-fat/sucrose diet for twelve weeks followed by induction of biliary inflammation by OVA-specific T cell transfer. Histopathological damage in portal tracts was scored and serum collected. Neutralizing antibodies against IL-15 were administered daily until study termination. Obese mice developed exacerbated liver inflammation and damage. Immune cell phenotyping in liver revealed greater numbers of neutrophils and CD8+ T cells in obese mice. Higher levels of cytokines and chemokines were found in obese mice with cholangitis. Immuno-neutralizing antibodies against IL-15 greatly attenuated cholangitis in obese mice. Obesity exacerbated experimental PSC in part by overproduction of IL-15. Timely targeting of IL-15 may slow the progression of PSC."xsd:string |
| http://purl.uniprot.org/citations/29449577 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-018-21112-7"xsd:string |
| http://purl.uniprot.org/citations/29449577 | http://purl.uniprot.org/core/author | "Reyes J.L."xsd:string |
| http://purl.uniprot.org/citations/29449577 | http://purl.uniprot.org/core/author | "Vo T."xsd:string |
| http://purl.uniprot.org/citations/29449577 | http://purl.uniprot.org/core/author | "Beck P.L."xsd:string |
| http://purl.uniprot.org/citations/29449577 | http://purl.uniprot.org/core/author | "Reimer R.A."xsd:string |
| http://purl.uniprot.org/citations/29449577 | http://purl.uniprot.org/core/author | "Eksteen B."xsd:string |
| http://purl.uniprot.org/citations/29449577 | http://purl.uniprot.org/core/author | "Gulamhusein A."xsd:string |
| http://purl.uniprot.org/citations/29449577 | http://purl.uniprot.org/core/author | "Vannan D.T."xsd:string |
| http://purl.uniprot.org/citations/29449577 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29449577 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/29449577 | http://purl.uniprot.org/core/pages | "3127"xsd:string |
| http://purl.uniprot.org/citations/29449577 | http://purl.uniprot.org/core/title | "Neutralization of IL-15 abrogates experimental immune-mediated cholangitis in diet-induced obese mice."xsd:string |
| http://purl.uniprot.org/citations/29449577 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/29449577 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29449577 |
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