| http://purl.uniprot.org/citations/29455326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29455326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29455326 | http://www.w3.org/2000/01/rdf-schema#comment | "Rotavirus nonstructural protein 4, the first viral enterotoxin to be identified, is a multidomain, multifunctional glycoprotein. Earlier, we reported a Ca2+-bound coiled-coil tetrameric structure of the diarrhea-inducing region of NSP4 from the rotavirus strains SA11 and I321 and a Ca2+-free pentameric structure from the rotavirus strain ST3, all with a parallel arrangement of α-helices. pH was found to determine the oligomeric state: a basic pH favoured a tetramer, whereas an acidic pH favoured a pentamer. Here, we report two novel forms of the coiled-coil region of NSP4 from the bovine rotavirus strains MF66 and NCDV. These crystallized at acidic pH, forming antiparallel coiled-coil tetrameric structures without any bound Ca2+ ion. Structural and mutational studies of the coiled-coil regions of NSP4 revealed that the nature of the residue at position 131 (Tyr/His) plays an important role in the observed structural diversity."xsd:string |
| http://purl.uniprot.org/citations/29455326 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00705-018-3753-6"xsd:string |
| http://purl.uniprot.org/citations/29455326 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00705-018-3753-6"xsd:string |
| http://purl.uniprot.org/citations/29455326 | http://purl.uniprot.org/core/author | "Kumar S."xsd:string |
| http://purl.uniprot.org/citations/29455326 | http://purl.uniprot.org/core/author | "Kumar S."xsd:string |
| http://purl.uniprot.org/citations/29455326 | http://purl.uniprot.org/core/author | "Rao C.D."xsd:string |
| http://purl.uniprot.org/citations/29455326 | http://purl.uniprot.org/core/author | "Rao C.D."xsd:string |
| http://purl.uniprot.org/citations/29455326 | http://purl.uniprot.org/core/author | "Suguna K."xsd:string |
| http://purl.uniprot.org/citations/29455326 | http://purl.uniprot.org/core/author | "Suguna K."xsd:string |
| http://purl.uniprot.org/citations/29455326 | http://purl.uniprot.org/core/author | "Pamidimukkala K."xsd:string |
| http://purl.uniprot.org/citations/29455326 | http://purl.uniprot.org/core/author | "Pamidimukkala K."xsd:string |
| http://purl.uniprot.org/citations/29455326 | http://purl.uniprot.org/core/author | "Ramappa R."xsd:string |
| http://purl.uniprot.org/citations/29455326 | http://purl.uniprot.org/core/author | "Ramappa R."xsd:string |
| http://purl.uniprot.org/citations/29455326 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29455326 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29455326 | http://purl.uniprot.org/core/name | "Arch. Virol."xsd:string |
| http://purl.uniprot.org/citations/29455326 | http://purl.uniprot.org/core/name | "Arch Virol"xsd:string |
| http://purl.uniprot.org/citations/29455326 | http://purl.uniprot.org/core/pages | "1531-1547"xsd:string |
| http://purl.uniprot.org/citations/29455326 | http://purl.uniprot.org/core/pages | "1531-1547"xsd:string |
| http://purl.uniprot.org/citations/29455326 | http://purl.uniprot.org/core/title | "New tetrameric forms of the rotavirus NSP4 with antiparallel helices."xsd:string |
| http://purl.uniprot.org/citations/29455326 | http://purl.uniprot.org/core/title | "New tetrameric forms of the rotavirus NSP4 with antiparallel helices."xsd:string |
| http://purl.uniprot.org/citations/29455326 | http://purl.uniprot.org/core/volume | "163"xsd:string |
| http://purl.uniprot.org/citations/29455326 | http://purl.uniprot.org/core/volume | "163"xsd:string |