| http://purl.uniprot.org/citations/29457037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29457037 | http://www.w3.org/2000/01/rdf-schema#comment | "Apical periodontitis (AP) is a chronic infection of endodontic origin accompanied with bone destruction around the apical region. Semaphorin3A (Sema3A) and neuropilin-1 (Nrp1) are regarded as a pair of immune regulators in bone metabolism. In this study, we firstly investigated the expression pattern of Sema3A/Nrp1 in apical periodontitis and its correlation with bone destruction. Using rat animal model, we analysed the level of mandibular bone destruction and the expression of Sema3A/Nrp1 on days 0, 7, 14, 21, 28, and 35 after pulp exposure. In addition, clinical samples from apical periodontitis patients were obtained to analyse the expression of Sema3A/Nrp1. These results indicated that the bone destruction level expanded from days 7 to 35. The number of positive cells and level of mRNA expression of Sema3A/Nrp1 were significantly decreased from days 7 to 35, with a negative correlation with bone destruction. Moreover, expression of Sema3A/Nrp1 in the AP group was reduced compared to the control group of clinical samples. In conclusion, decreased expression of Sema3A/Nrp1 was observed in periapical lesions and is potentially involved in the bone resorption of the periapical area, suggesting that Sema3A/Nrp1 may contribute to the pathological development of apical periodontitis."xsd:string |
| http://purl.uniprot.org/citations/29457037 | http://purl.org/dc/terms/identifier | "doi:10.1155/2017/8724503"xsd:string |
| http://purl.uniprot.org/citations/29457037 | http://purl.uniprot.org/core/author | "Lin Z."xsd:string |
| http://purl.uniprot.org/citations/29457037 | http://purl.uniprot.org/core/author | "Lin Y."xsd:string |
| http://purl.uniprot.org/citations/29457037 | http://purl.uniprot.org/core/author | "Xu M."xsd:string |
| http://purl.uniprot.org/citations/29457037 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/29457037 | http://purl.uniprot.org/core/author | "Qin W."xsd:string |
| http://purl.uniprot.org/citations/29457037 | http://purl.uniprot.org/core/author | "Xing Q."xsd:string |
| http://purl.uniprot.org/citations/29457037 | http://purl.uniprot.org/core/author | "Zou R."xsd:string |
| http://purl.uniprot.org/citations/29457037 | http://purl.uniprot.org/core/author | "Xu H.H.K."xsd:string |
| http://purl.uniprot.org/citations/29457037 | http://purl.uniprot.org/core/author | "de Melo M.A.S."xsd:string |
| http://purl.uniprot.org/citations/29457037 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/29457037 | http://purl.uniprot.org/core/name | "Biomed Res Int"xsd:string |
| http://purl.uniprot.org/citations/29457037 | http://purl.uniprot.org/core/pages | "8724503"xsd:string |
| http://purl.uniprot.org/citations/29457037 | http://purl.uniprot.org/core/title | "Decreased Expression of Semaphorin3A/Neuropilin-1 Signaling Axis in Apical Periodontitis."xsd:string |
| http://purl.uniprot.org/citations/29457037 | http://purl.uniprot.org/core/volume | "2017"xsd:string |
| http://purl.uniprot.org/citations/29457037 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29457037 |
| http://purl.uniprot.org/citations/29457037 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29457037 |
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| http://purl.uniprot.org/uniprot/#_A6K213-mappedCitation-29457037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29457037 |
| http://purl.uniprot.org/uniprot/#_A8K9V7-mappedCitation-29457037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29457037 |
| http://purl.uniprot.org/uniprot/#_O14786-mappedCitation-29457037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29457037 |
| http://purl.uniprot.org/uniprot/#_Q63548-mappedCitation-29457037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29457037 |
| http://purl.uniprot.org/uniprot/#_Q59F20-mappedCitation-29457037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29457037 |