| http://purl.uniprot.org/citations/29458021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29458021 | http://www.w3.org/2000/01/rdf-schema#comment | "We previously showed that the mitochondrial fatty acid oxidation enzyme long-chain acyl-CoA dehydrogenase (LCAD) is expressed in alveolar type II pneumocytes and that LCAD-/-mice have altered breathing mechanics and surfactant defects. Here, we hypothesized that LCAD-/-mice would be susceptible to influenza infection. Indeed, LCAD-/-mice demonstrated increased mortality following infection with 2009 pandemic influenza (A/CA/07/09). However, the mortality was not due to increased lung injury, as inflammatory cell counts, viral titers, and histology scores all showed non-significant trends toward milder injury in LCAD-/-mice. To confirm this, LCAD-/-were infected with a second, mouse-adapted H1N1 virus (A/PR/8/34), to which they responded with significantly less lung injury. While both strains become increasingly hypoglycemic over the first week post-infection, LCAD-/-mice lose body weight more rapidly than wild-type mice. Surprisingly, while acutely fasted LCAD-/-mice develop hepatic steatosis, influenza-infected LCAD-/-mice do not. They do, however, become more hypothermic than wild-type mice and demonstrate increased blood lactate values. We conclude that LCAD-/-mice succumb to influenza from bioenergetic starvation, likely due to increased reliance upon glucose for energy."xsd:string |
| http://purl.uniprot.org/citations/29458021 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2018.02.135"xsd:string |
| http://purl.uniprot.org/citations/29458021 | http://purl.uniprot.org/core/author | "Luo J."xsd:string |
| http://purl.uniprot.org/citations/29458021 | http://purl.uniprot.org/core/author | "Shi H."xsd:string |
| http://purl.uniprot.org/citations/29458021 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/29458021 | http://purl.uniprot.org/core/author | "Beck M.E."xsd:string |
| http://purl.uniprot.org/citations/29458021 | http://purl.uniprot.org/core/author | "Bharathi S.S."xsd:string |
| http://purl.uniprot.org/citations/29458021 | http://purl.uniprot.org/core/author | "Goetzman E.S."xsd:string |
| http://purl.uniprot.org/citations/29458021 | http://purl.uniprot.org/core/author | "Shinde A."xsd:string |
| http://purl.uniprot.org/citations/29458021 | http://purl.uniprot.org/core/author | "Alcorn J.F."xsd:string |
| http://purl.uniprot.org/citations/29458021 | http://purl.uniprot.org/core/author | "McHugh K.J."xsd:string |
| http://purl.uniprot.org/citations/29458021 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29458021 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/29458021 | http://purl.uniprot.org/core/pages | "700-704"xsd:string |
| http://purl.uniprot.org/citations/29458021 | http://purl.uniprot.org/core/title | "Increased mortality from influenza infection in long-chain acyl-CoA dehydrogenase knockout mice."xsd:string |
| http://purl.uniprot.org/citations/29458021 | http://purl.uniprot.org/core/volume | "497"xsd:string |
| http://purl.uniprot.org/citations/29458021 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29458021 |
| http://purl.uniprot.org/citations/29458021 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29458021 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J083-mappedCitation-29458021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29458021 |
| http://purl.uniprot.org/uniprot/#_P51174-mappedCitation-29458021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29458021 |
| http://purl.uniprot.org/uniprot/P51174 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/29458021 |
| http://purl.uniprot.org/uniprot/A0A0R4J083 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/29458021 |