| http://purl.uniprot.org/citations/29463868 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29463868 | http://www.w3.org/2000/01/rdf-schema#comment | "In this study, we investigated the role of CD38 in a pristane-induced murine model of lupus. CD38-deficient (Cd38-/-) but not ART2-deficient (Art2-/-) mice developed less severe lupus compared to wild type (WT) mice, and their protective phenotype consisted of (i) decreased IFN-I-stimulated gene expression, (ii) decreased numbers of peritoneal CCR2hiLy6Chi inflammatory monocytes, TNF-α-producing Ly6G+ neutrophils and Ly6Clo monocytes/macrophages, (iii) decreased production of anti-single-stranded DNA and anti-nRNP autoantibodies, and (iv) ameliorated glomerulonephritis. Cd38-/- pristane-elicited peritoneal exudate cells had defective CCL2 and TNF-α secretion following TLR7 stimulation. However, Tnf-α and Cxcl12 gene expression in Cd38-/- bone marrow (BM) cells was intact, suggesting a CD38-independent TLR7/TNF-α/CXCL12 axis in the BM. Chemotactic responses of Cd38-/- Ly6Chi monocytes and Ly6G+ neutrophils were not impaired. However, Cd38-/- Ly6Chi monocytes and Ly6Clo monocytes/macrophages had defective apoptosis-mediated cell death. Importantly, mice lacking the cation channel TRPM2 (Trpm2-/-) exhibited very similar protection, with decreased numbers of PECs, and apoptotic Ly6Chi monocytes and Ly6Clo monocytes/macrophages compared to WT mice. These findings reveal a new role for CD38 in promoting aberrant inflammation and lupus-like autoimmunity via an apoptosis-driven mechanism. Furthermore, given the implications of CD38 in the activation of TRPM2, our data suggest that CD38 modulation of pristane-induced apoptosis is TRPM2-dependent."xsd:string |
| http://purl.uniprot.org/citations/29463868 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-018-21337-6"xsd:string |
| http://purl.uniprot.org/citations/29463868 | http://purl.uniprot.org/core/author | "Koch-Nolte F."xsd:string |
| http://purl.uniprot.org/citations/29463868 | http://purl.uniprot.org/core/author | "Mack M."xsd:string |
| http://purl.uniprot.org/citations/29463868 | http://purl.uniprot.org/core/author | "Sancho J."xsd:string |
| http://purl.uniprot.org/citations/29463868 | http://purl.uniprot.org/core/author | "Lund F.E."xsd:string |
| http://purl.uniprot.org/citations/29463868 | http://purl.uniprot.org/core/author | "Corbi A."xsd:string |
| http://purl.uniprot.org/citations/29463868 | http://purl.uniprot.org/core/author | "Lo Buono N."xsd:string |
| http://purl.uniprot.org/citations/29463868 | http://purl.uniprot.org/core/author | "Botta D."xsd:string |
| http://purl.uniprot.org/citations/29463868 | http://purl.uniprot.org/core/author | "Merino R."xsd:string |
| http://purl.uniprot.org/citations/29463868 | http://purl.uniprot.org/core/author | "Zubiaur M."xsd:string |
| http://purl.uniprot.org/citations/29463868 | http://purl.uniprot.org/core/author | "Garcia-Rodriguez S."xsd:string |
| http://purl.uniprot.org/citations/29463868 | http://purl.uniprot.org/core/author | "Guerrero S."xsd:string |
| http://purl.uniprot.org/citations/29463868 | http://purl.uniprot.org/core/author | "Rosal-Vela A."xsd:string |
| http://purl.uniprot.org/citations/29463868 | http://purl.uniprot.org/core/author | "Zumaquero E."xsd:string |
| http://purl.uniprot.org/citations/29463868 | http://purl.uniprot.org/core/author | "Cerezo-Wallis D."xsd:string |
| http://purl.uniprot.org/citations/29463868 | http://purl.uniprot.org/core/author | "Andres-Leon E."xsd:string |
| http://purl.uniprot.org/citations/29463868 | http://purl.uniprot.org/core/author | "Cumba Garcia L.M."xsd:string |
| http://purl.uniprot.org/citations/29463868 | http://purl.uniprot.org/core/author | "Gonzalez-Paredes E."xsd:string |
| http://purl.uniprot.org/citations/29463868 | http://purl.uniprot.org/core/author | "Prados-Maniviesa V."xsd:string |
| http://purl.uniprot.org/citations/29463868 | http://purl.uniprot.org/core/author | "Robles-Guirado J.A."xsd:string |
| http://purl.uniprot.org/citations/29463868 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29463868 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/29463868 | http://purl.uniprot.org/core/pages | "3357"xsd:string |